Ependymoma stem cells are highly sensitive to temozolomide in vitro and in orthotopic models

Daniela Meco; Tiziana Servidei; Giuseppe Lamorte; Elena Binda; Vincenzo Arena; Riccardo Riccardi

doi:10.1093/neuonc/nou008

Ependymoma stem cells are highly sensitive to temozolomide in vitro and in orthotopic models

Daniela Meco, Tiziana Servidei, Giuseppe Lamorte, Elena Binda, Vincenzo Arena, Riccardo Riccardi

Faculty of Medicine and Surgery

Research output: Contribution to journal › Article

15 Citations (Scopus)

Abstract

Ependymoma management remains challenging because of the inherent chemoresistance of this tumor. To determine whether ependymoma stem cells (SCs) might contribute to therapy resistance, we investigated the sensitivity of ependymoma SCs to temozolomide and etoposide.

Original language	English
Pages (from-to)	N/A-N/A
Journal	Neuro-Oncology
DOIs	https://doi.org/10.1093/neuonc/nou008
Publication status	Published - 2014

Keywords

MGMT
differentiation
ependymoma stem cells
orthotopic models
temozolomide

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10.1093/neuonc/nou008

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title = "Ependymoma stem cells are highly sensitive to temozolomide in vitro and in orthotopic models",

abstract = "Ependymoma management remains challenging because of the inherent chemoresistance of this tumor. To determine whether ependymoma stem cells (SCs) might contribute to therapy resistance, we investigated the sensitivity of ependymoma SCs to temozolomide and etoposide.",

keywords = "MGMT, differentiation, ependymoma stem cells, orthotopic models, temozolomide, MGMT, differentiation, ependymoma stem cells, orthotopic models, temozolomide",

author = "Daniela Meco and Tiziana Servidei and Giuseppe Lamorte and Elena Binda and Vincenzo Arena and Riccardo Riccardi",

year = "2014",

doi = "10.1093/neuonc/nou008",

language = "English",

pages = "N/A--N/A",

journal = "Neuro-Oncology",

issn = "1522-8517",

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T1 - Ependymoma stem cells are highly sensitive to temozolomide in vitro and in orthotopic models

AU - Meco, Daniela

AU - Servidei, Tiziana

AU - Lamorte, Giuseppe

AU - Binda, Elena

AU - Arena, Vincenzo

AU - Riccardi, Riccardo

PY - 2014

Y1 - 2014

N2 - Ependymoma management remains challenging because of the inherent chemoresistance of this tumor. To determine whether ependymoma stem cells (SCs) might contribute to therapy resistance, we investigated the sensitivity of ependymoma SCs to temozolomide and etoposide.

AB - Ependymoma management remains challenging because of the inherent chemoresistance of this tumor. To determine whether ependymoma stem cells (SCs) might contribute to therapy resistance, we investigated the sensitivity of ependymoma SCs to temozolomide and etoposide.

KW - MGMT

KW - differentiation

KW - ependymoma stem cells

KW - orthotopic models

KW - temozolomide

KW - MGMT

KW - differentiation

KW - ependymoma stem cells

KW - orthotopic models

KW - temozolomide

UR - http://hdl.handle.net/10807/55973

U2 - 10.1093/neuonc/nou008

DO - 10.1093/neuonc/nou008

M3 - Article

SN - 1522-8517

SP - N/A-N/A

JO - Neuro-Oncology

JF - Neuro-Oncology

ER -

Ependymoma stem cells are highly sensitive to temozolomide in vitro and in orthotopic models

Abstract

Keywords

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