Environmental enrichment potentiates thalamocortical transmission and plasticity in the adult rat visual cortex

Marco Mainardi, S Landi, L Gianfranceschi, S Baldini, R De Pasquale, N Berardi, L Maffei, M. Caleo

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

It has been demonstrated that the complex sensorimotor and social stimulation achieved by rearing animals in an enriched environment (EE) can reinstate juvenile-like plasticity in the adult cortex. However, it is not known whether EE can affect thalamocortical transmission. Here, we recorded in vivo field potentials from the visual cortex evoked by electrical stimulation of the dorsal lateral geniculate nucleus (dLGN) in anesthetized rats. We found that a period of EE during adulthood shifted the input-output curves and increased paired-pulse depression, suggesting an enhanced synaptic strength at thalamocortical terminals. Accordingly, EE animals showed an increased expression of the vesicular glutamate transporter 2 (vGluT-2) in geniculocortical afferents to layer IV. Rats reared in EE also showed an enhancement of thalamocortical long-term potentiation (LTP) triggered by theta-burst stimulation (TBS) of the dLGN. To monitor the functional consequences of increased LTP in EE rats, we recorded visual evoked potentials (VEPs) before and after application of TBS to the geniculocortical pathway. We found that responses to visual stimulation were enhanced across a range of contrasts in EE animals. This was accompanied by an up-regulation of the intracortical excitatory synaptic marker vGluT-1 and a decrease in the expression of the vesicular GABA transporter (vGAT), indicating a shift in the excitation/inhibition ratio. Thus, in the adult rat, EE enhances synaptic strength and plasticity of the thalamocortical pathway associated with specific changes in glutamatergic and GABAergic neurotransmission. These data provide novel insights into the mechanisms by which EE shapes the adult brain.
Original languageEnglish
Pages (from-to)3048-3059
Number of pages12
JournalJournal of Neuroscience Research
Volume88
DOIs
Publication statusPublished - 2010

Keywords

  • Animals
  • Environment, Controlled
  • Geniculate Bodies
  • Neuronal Plasticity
  • Physical Stimulation
  • Rats
  • Rats, Long-Evans
  • Synaptic Transmission
  • Visual Cortex
  • Visual Pathways

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