Enhanced BDNF serum levels in patients with severe pathological gambling

F Angelucci, Giovanni Martinotti, F Gelfo, Elisabetta Righino, Gianluigi Conte, C Caltagirone, Pietro Bria, Valerio Ricci

Research output: Contribution to journalArticle


Although the pathophysiology of gambling is unknown, an involvement of midbrain dopaminergic pathway has been hypothesized. In this study, the association between brain-derived neurotrophic factor (BDNF) and pathological gambling was investigated. We measured BDNF serum levels in (1) video players (n = 10); (2) card players (n = 9); (3) mixed players (n = 21; both video and card players) and (4) age-matched controls (n = 18). Mixed players had increased BDNF serum levels as compared to controls and higher South Oaks Gambling Screen score as compared to card or video players. Thus, the data demonstrate that patients affected by severe pathological gambling show enhanced BDNF serum levels.
Original languageEnglish
Pages (from-to)N/A-N/A
JournalAddiction Biology
Publication statusPublished - 2011
Externally publishedYes


  • BDNF
  • SOGS
  • dopamine
  • pathological gambling
  • serum levels


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