Enhanced BDNF serum levels in patients with severe pathological gambling

Giovanni Martinotti, Elisabetta Righino, Gianluigi Conte, Pietro Bria, F Angelucci, F Gelfo, C Caltagirone

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Although the pathophysiology of gambling is unknown, an involvement of midbrain dopaminergic pathway has been hypothesized. In this study, the association between brain-derived neurotrophic factor (BDNF) and pathological gamblingwas investigated.We measured BDNF serum levels in (1) video players (n = 10); (2) card players (n = 9); (3) mixed players (n = 21; both video and card players) and (4) age-matched controls (n = 18). Mixed players had increased BDNF serum levels as compared to controls and higher South Oaks Gambling Screen score as compared to card or video players. Thus, the data demonstrate that patients affected by severe pathological gambling showenhanced BDNF serum levels.
Original languageEnglish
Pages (from-to)749-751
Number of pages3
JournalAddiction Biology
Publication statusPublished - 2011


  • BDNF
  • SOGS
  • dopamine
  • pathologic gambling


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