Endothelial and platelet function in children with previous Kawasaki disease

Angelica Bibiana Delogu, Alfonso Sestito, Gaetano Antonio Lanza, Filippo Crea, Marianna Laurito, Alessandra Stazi, Maria Milo, Irma Battipaglia, Giancarla Scalone, Fabio Infusino, Angelo Villano, Giulio Russo, Rossella Iannotta, Costantino Romagnoli

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We investigated whether children with a previous Kawasaki disease (KD) have evidence of abnormal vascular and/or platelet function. We included 14 patients with previous KD and 14 matched controls. We assessed endothelial function by flow-mediated dilation (FMD), carotid intima-media thickness (cIMT), coronary microvascular function by coronary blood flow response (CBFR) to cold pressor test, and platelet reactivity by measuring monocyte-platelet aggregates (MPAs) and CD41-platelet expression by flow cytometry. No differences were found between the groups in FMD, cIMT, or CBFR to cold pressor test. The MPAs were similar in patients with KD and controls. CD41-platelet expression, however, was significantly increased in patients with KD compared with controls, both at rest (14.3 ± 1.9 vs 12.4 ± 1.9 mean fluorescence intensity [mfi], P = .01) and after adenosine diphosphate stimulation (19.3 ± 1.3 vs 17 ± 1.7 mfi, P < .001). In conclusion, children with a previous episode of KD showed increased platelet activation, compared with healthy participants despite no apparent vascular abnormality at follow-up.
Original languageEnglish
Pages (from-to)716-722
Number of pages7
JournalAngiology
Volume65
DOIs
Publication statusPublished - 2014

Keywords

  • Adolescent
  • Blood Platelets
  • Carotid Intima-Media Thickness
  • Child
  • Child, Preschool
  • Endothelium, Vascular
  • Female
  • Humans
  • Kawasaki disease
  • Male
  • Mucocutaneous Lymph Node Syndrome
  • Platelet Activation
  • Platelet Aggregation
  • Platelet Function Tests
  • carotid intima-medial thickness
  • endothelial function
  • platelet function

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