Endocrine status in patients with mammary gland diseases: correlation between steroid hormones and sex steroid binding globulin

Celestino Pio Lombardi, Rocco Domenico Alfonso Bellantone, Anna Paola Mancini, Laura De Marinis Grasso, Sabrina Rossi, C Di Pietro, I Liberale, E Menini, F. Crucitti

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We have studied 131 women affected by benign or malignant breast disease, in order to explore their endocrine status. We evaluated basal concentrations of the following hormones: FSH, LH, PRL, estrone (E1), estradiol (E2), testosterone (T), androstenedione (A), DHEAS and SHBG. Basal hormone levels in these patients were not significantly different from those in normal age-matched subjects. However, in premenopausal women, 31% of patients with benign disease and 34.4% with malignant lumps exhibited an elevated FSH/LH ratio (greater than 1) and lower T levels, compared to those having a normal FSH/LH ratio. The difference in T levels was not coupled with the expected specular variations in SHBG levels. Moreover, in none of the group considered, T concentrations or E2/T were significantly correlated with SHBG levels. These data seem to suggest an altered regulation of SHBG in these patients, in whom the modulation of SHBG by circulating sexual steroids appears to be different when compared with normal subjects.
Original languageEnglish
Pages (from-to)101-108
Number of pages8
JournalGynecological Endocrinology
Volume5
Publication statusPublished - 1991

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Androstenedione
  • Breast Neoplasms
  • Dehydroepiandrosterone
  • Dehydroepiandrosterone Sulfate
  • Estradiol
  • Estrone
  • Female
  • Follicle Stimulating Hormone
  • Hormones
  • Humans
  • Luteinizing Hormone
  • Menopause
  • Menstruation
  • Middle Aged
  • Prolactin
  • Sex Hormone-Binding Globulin
  • Testosterone

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