Endocrine and Metabolic Insights from Pancreatic Surgery

Teresa Mezza, Giuseppe Quero, Alfredo Pontecorvi, Sergio Alfieri, Andrea Giaccari, Chiara Maria Assunta Cefalo, Francesca Cinti, Jens J. Holst

Research output: Contribution to journalArticle

2 Citations (Scopus)


Although it is well established that diabetes can also develop as a result of diseases or maneuvers on the exocrine pancreas, the complex relationship between glucose disorders and underlying pancreatic disease is still debated. There is evidence that several features linked to pancreatic diseases can modify endocrine and metabolic conditions before and after surgery. However, pancreatic surgery provides a rare opportunity to correlate in vivo endocrine and metabolic pathways with ex vivo pancreatic samples, to examine the endocrine and metabolic effects of acute islet removal, and finally to clarify the pathogenesis of diabetes. This approach could therefore represent a unique method to shed light on the molecular mechanisms, predicting factors, and metabolic consequences of insulin resistance, islet plasticity, β cell failure, and type 2 diabetes.
Original languageEnglish
Pages (from-to)760-772
Number of pages13
JournalTrends in Endocrinology and Metabolism
Publication statusPublished - 2020


  • pancreatic disease
  • pancreatic surgery
  • personalized medicine
  • type 2 diabetes mellitus


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