Eltrombopag in paediatric immune thrombocytopenia: Iron metabolism modulation in mesenchymal stromal cells

Alessandra Di Paola, Giuseppe Palumbo, Chiara Tortora, Maura Argenziano, Marialuigia Catanoso, Caterina Di Leva, Giulia Ceglie, Silverio Perrotta, Franco Locatelli, Francesca Rossi

Research output: Contribution to journalArticle

Abstract

Immune thrombocytopenia (ITP) is an autoimmune disease caused by platelet destruction mediated by auto-antibody production. It is characterized by a compromised immune system and alteration of the inflammatory response. Mesenchymal stromal cells (MSCs) play an important role in modulating immune and inflammatory processes, exerting immune-suppressing and anti-inflammatory properties. In ITP-MSCs the activity and survival are strongly impaired. Eltrombopag (ELT) is a thrombopoietin receptor agonist approved in chronic ITP for stimulating platelet production. It has immunomodulating properties by stimulating T and B regulatory cell activity and by promoting a macrophage switch from the pro-inflammatory to the anti-inflammatory phenotype. ELT also exhibits iron-chelating properties. Iron is a crucial element involved in several physiologic processes, but its intracellular accumulation determines cell damages. Therefore, for the first time we analysed the effect of ELT on ITP-MSCs demonstrating its ability to restore survival and activity of MSCs directly and to promote their survival and proliferation indirectly, by iron metabolism modulation.
Original languageEnglish
Pages (from-to)110-119
Number of pages10
JournalBritish Journal of Haematology
Volume197
DOIs
Publication statusPublished - 2022

Keywords

  • eltrombopag
  • mesenchymal stromal cells
  • iron metabolism
  • immune thrombocytopenia

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