Electric fields for the treatment of glioblastoma

Angelo Pompucci, Pasquale De Bonis, Francesco Doglietto, Carmelo Anile, Annunziato Mangiola

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Glioblastoma (GBM) is the most common primary malignant cerebral tumor in adults, with a poor prognosis despite several therapeutic efforts. Electric fields (EFs) have shown promising results as a new anticancer treatment. Stupp et al. report on the first Phase III trial comparing EF versus chemotherapy in patients with recurrent GBM. The study was designed for superiority; although well conducted, it might not have shown it for a limited compliance in the EF group. Even with this limitation, the trial has shown at least equivalence of EF to chemotherapy, with a decreased toxicity and increased quality of life favoring EF. Further basic and clinical studies are warranted to increase knowledge, efficacy, compliance and cost-effectiveness. This trial has opened a new promising field in GBM treatment.
Original languageEnglish
Pages (from-to)1181-1184
Number of pages4
JournalEXPERT REVIEW NEUROTHERAPEUTICS
Volume12
DOIs
Publication statusPublished - 2012

Keywords

  • electric fields
  • glioblastoma

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