Elective-high frequency oscillatory ventilation in preterm infants with respiratory distress syndrome: an individual patients data meta-analysis

Filip Cools, Lisa Askie, Martin Offringa, Jeanette Asselin, Sandra Calvert, Sherry Courtney, Carlo Dani, David Durand, Dale Gerstmann, David Henderson Smart, Neil Marlow, Janet Peacock, Jane Pillow, Roger Soll, Ulrich Thome, Patrick Truffert, Michael Schreiber, Patrick Van Reempts, Valentina Vendettuoli, Giovanni Vento

Research output: Contribution to journalArticle

Abstract

[Autom. eng. transl.] BACKGROUND: Population and study design heterogeneity has confounded previous meta-analyzes, leading to uncertainty about effectiveness and elective high-frequency oscillatory ventilation (HFOV) in preterm infants. We assessed effectiveness of elective HFOV versus conventional ventilation in this group. METHODS: We did a systematic review and meta-analysis of individual patients 'data from 3229 participants in ten randomized controlled trials, with the primary outcomes of death or bronchopulmonary dysplasia at 36 weeks' postmenstrual age, death or severe adverse neurological event, or any of these outcomes. FINDINGS: For infants ventilated with HFOV, the relative risk of death or bronchopulmonary dysplasia at 36 weeks' postmenstrual age was 0.95 (95% CI 0.88-1.03), of death or severe adverse neurological event 1.00 (0.88-1.13), or any of these outcomes 0.98 (0.91-1.05). No subgroup of infants (eg, gestational age, birthweight for pregnancy, initial lung disease severity, or exposure to antenatal corticosteroids). Ventilator type gold ventilation strategy did not change the overall treatment effect. INTERPRETATION: HFOV seems to be effective in preterm infants. Our results of pregnancy, pregnancy, birth weight, pregnancy, pregnancy, pregnancy, pregnancy, pregnancy, pregnancy, pregnancy, pregnancy, or FUNDING: Nestlé Belgium, Belgian Red Cross, and Dräger International.
Original languageEnglish
Pages (from-to)2082-2091
Number of pages10
JournalThe Lancet
Publication statusPublished - 2010

Keywords

  • IP meta-analysis

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