Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BacT/Alert or Bactec Resin-Containing Media in Simulated Adult Blood Cultures

Giulia De Angelis; Maurizio Sanguinetti; Teresa Spanu; Brunella Posteraro; Giulia Menchinelli; Liliana Giordano

doi:10.1128/AAC.00420-19

Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BacT/Alert or Bactec Resin-Containing Media in Simulated Adult Blood Cultures

Giulia De Angelis, Maurizio Sanguinetti, Teresa Spanu, Brunella Posteraro, Giulia Menchinelli, Liliana Giordano

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We assessed the antimicrobial-inactivation capability of BacT/Alert (FA Plus and FN Plus) or Bactec (Plus Aerobic/F and Plus Anaerobic/F) media for 40 antibiotic-bacterium combinations in simulated adult blood cultures. Aside from high recovery rates (93.2% and 88.4%, respectively), we showed that at the lowest but clinically relevant antibiotic concentrations, both BacT/Alert and Bactec media recovered all the organisms tested with drugs except for Escherichia coli, which was tested in the presence of meropenem. Delayed recoveries were mainly associated with vancomycin.

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	Antimicrobial Agents and Chemotherapy
Volume	2019/63
DOIs	https://doi.org/10.1128/AAC.00420-19
Publication status	Published - 2019

Keywords

NEUTRALIZATION OF ANTIMICROBIALS

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10.1128/AAC.00420-19

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title = "Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BacT/Alert or Bactec Resin-Containing Media in Simulated Adult Blood Cultures",

abstract = "We assessed the antimicrobial-inactivation capability of BacT/Alert (FA Plus and FN Plus) or Bactec (Plus Aerobic/F and Plus Anaerobic/F) media for 40 antibiotic-bacterium combinations in simulated adult blood cultures. Aside from high recovery rates (93.2% and 88.4%, respectively), we showed that at the lowest but clinically relevant antibiotic concentrations, both BacT/Alert and Bactec media recovered all the organisms tested with drugs except for Escherichia coli, which was tested in the presence of meropenem. Delayed recoveries were mainly associated with vancomycin.",

keywords = "NEUTRALIZATION OF ANTIMICROBIALS, NEUTRALIZATION OF ANTIMICROBIALS",

author = "{De Angelis}, Giulia and Maurizio Sanguinetti and Teresa Spanu and Brunella Posteraro and Giulia Menchinelli and Liliana Giordano",

year = "2019",

doi = "10.1128/AAC.00420-19",

language = "English",

volume = "2019/63",

pages = "1--10",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology:PO Box 11127:Birmingham, AL 35201:(800)633-4931, (205)995-1567, EMAIL: asm.nonmembers.subs@ebsco.com, INTERNET: http://www.asm.org, Fax: (205)995-1588",

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Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BacT/Alert or Bactec Resin-Containing Media in Simulated Adult Blood Cultures. / De Angelis, Giulia ; Sanguinetti, Maurizio ; Spanu, Teresa ; Posteraro, Brunella; Menchinelli, Giulia; Giordano, Liliana.

In: Antimicrobial Agents and Chemotherapy, Vol. 2019/63, 2019, p. 1-10.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BacT/Alert or Bactec Resin-Containing Media in Simulated Adult Blood Cultures

AU - De Angelis, Giulia

AU - Sanguinetti, Maurizio

AU - Spanu, Teresa

AU - Posteraro, Brunella

AU - Menchinelli, Giulia

AU - Giordano, Liliana

PY - 2019

Y1 - 2019

N2 - We assessed the antimicrobial-inactivation capability of BacT/Alert (FA Plus and FN Plus) or Bactec (Plus Aerobic/F and Plus Anaerobic/F) media for 40 antibiotic-bacterium combinations in simulated adult blood cultures. Aside from high recovery rates (93.2% and 88.4%, respectively), we showed that at the lowest but clinically relevant antibiotic concentrations, both BacT/Alert and Bactec media recovered all the organisms tested with drugs except for Escherichia coli, which was tested in the presence of meropenem. Delayed recoveries were mainly associated with vancomycin.

AB - We assessed the antimicrobial-inactivation capability of BacT/Alert (FA Plus and FN Plus) or Bactec (Plus Aerobic/F and Plus Anaerobic/F) media for 40 antibiotic-bacterium combinations in simulated adult blood cultures. Aside from high recovery rates (93.2% and 88.4%, respectively), we showed that at the lowest but clinically relevant antibiotic concentrations, both BacT/Alert and Bactec media recovered all the organisms tested with drugs except for Escherichia coli, which was tested in the presence of meropenem. Delayed recoveries were mainly associated with vancomycin.

KW - NEUTRALIZATION OF ANTIMICROBIALS

UR - http://hdl.handle.net/10807/154499

U2 - 10.1128/AAC.00420-19

DO - 10.1128/AAC.00420-19

M3 - Article

VL - 2019/63

SP - 1

EP - 10

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

ER -

Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BacT/Alert or Bactec Resin-Containing Media in Simulated Adult Blood Cultures

Abstract

Keywords

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