Efficacy of contrast medium induced Pd/Pa ratio in predicting functional significance of intermediate coronary artery stenosis assessed by fractional flow reserve: insights from the RINASCI study

Antonio Maria Leone; Giancarla Scalone; Giovanni Luigi De Maria; F Tagliaferro; A Gardi; Francesca Di Clemente; Eloisa Basile; Pio Cialdella; Alberto De Caterina; Italo Porto; Cristina Aurigemma; Francesco Burzotta; Giampaolo Niccoli; Carlo Trani; Antonio Giuseppe Rebuzzi; Filippo Crea

doi:10.4244/EIJY14M07_02

Efficacy of contrast medium induced Pd/Pa ratio in predicting functional significance of intermediate coronary artery stenosis assessed by fractional flow reserve: insights from the RINASCI study

Antonio Maria Leone^*
, Giancarla Scalone
, Giovanni Luigi De Maria
, F Tagliaferro
, A Gardi
, Francesca Di Clemente
, Eloisa Basile
, Pio Cialdella
, Alberto De Caterina
, Italo Porto
, Cristina Aurigemma
, Francesco Burzotta
, Giampaolo Niccoli
, Carlo Trani
, Antonio Giuseppe Rebuzzi
, Filippo Crea

^*Corresponding author

IRCCS Policlinico San Donato

Research output: Contribution to journal › Article

49 Citations (Scopus)

Abstract

The need of adenosine administration for the achievement of maximal hyperaemia limits the widespread application of fractional flow reserve (FFR) in the real world. We hypothesised that Pd/Pa ratio registered during submaximal reactive hyperaemia induced by conventional non-ionic radiographic contrast medium (contrast medium induced Pd/Pa ratio: CMR) can be sufficient for the assessment of physiological severity of stenosis in the vast majority of cases. The aim of the present study was to test the accuracy of CMR in comparison to FFR.

Original language	English
Pages (from-to)	421-427
Number of pages	7
Journal	EuroIntervention
Volume	11
Issue number	4
DOIs	https://doi.org/10.4244/EIJY14M07_02
Publication status	Published - 2015

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

Keywords

fractional flow reserve
stenosis

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10.4244/EIJY14M07_02

Cite this

Leone, A. M., Scalone, G., De Maria, G. L., Tagliaferro, F., Gardi, A., Di Clemente, F., Basile, E., Cialdella, P., De Caterina, A., Porto, I., Aurigemma, C., Burzotta, F., Niccoli, G., Trani, C., Rebuzzi, A. G., & Crea, F. (2015). Efficacy of contrast medium induced Pd/Pa ratio in predicting functional significance of intermediate coronary artery stenosis assessed by fractional flow reserve: insights from the RINASCI study. EuroIntervention, 11(4), 421-427. https://doi.org/10.4244/EIJY14M07_02

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title = "Efficacy of contrast medium induced Pd/Pa ratio in predicting functional significance of intermediate coronary artery stenosis assessed by fractional flow reserve: insights from the RINASCI study",

abstract = "The need of adenosine administration for the achievement of maximal hyperaemia limits the widespread application of fractional flow reserve (FFR) in the real world. We hypothesised that Pd/Pa ratio registered during submaximal reactive hyperaemia induced by conventional non-ionic radiographic contrast medium (contrast medium induced Pd/Pa ratio: CMR) can be sufficient for the assessment of physiological severity of stenosis in the vast majority of cases. The aim of the present study was to test the accuracy of CMR in comparison to FFR.",

keywords = "fractional flow reserve, stenosis, fractional flow reserve, stenosis",

author = "Leone, \{Antonio Maria\} and Giancarla Scalone and \{De Maria\}, \{Giovanni Luigi\} and F Tagliaferro and A Gardi and \{Di Clemente\}, Francesca and Eloisa Basile and Pio Cialdella and \{De Caterina\}, Alberto and Italo Porto and Cristina Aurigemma and Francesco Burzotta and Giampaolo Niccoli and Carlo Trani and Rebuzzi, \{Antonio Giuseppe\} and Filippo Crea",

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Leone, AM, Scalone, G, De Maria, GL, Tagliaferro, F, Gardi, A, Di Clemente, F, Basile, E, Cialdella, P, De Caterina, A, Porto, I, Aurigemma, C, Burzotta, F, Niccoli, G, Trani, C, Rebuzzi, AG & Crea, F 2015, 'Efficacy of contrast medium induced Pd/Pa ratio in predicting functional significance of intermediate coronary artery stenosis assessed by fractional flow reserve: insights from the RINASCI study', EuroIntervention, vol. 11, no. 4, pp. 421-427. https://doi.org/10.4244/EIJY14M07_02

Efficacy of contrast medium induced Pd/Pa ratio in predicting functional significance of intermediate coronary artery stenosis assessed by fractional flow reserve: insights from the RINASCI study. / Leone, Antonio Maria; Scalone, Giancarla; De Maria, Giovanni Luigi et al.
In: EuroIntervention, Vol. 11, No. 4, 2015, p. 421-427.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Efficacy of contrast medium induced Pd/Pa ratio in predicting functional significance of intermediate coronary artery stenosis assessed by fractional flow reserve: insights from the RINASCI study

AU - Leone, Antonio Maria

AU - Scalone, Giancarla

AU - De Maria, Giovanni Luigi

AU - Tagliaferro, F

AU - Gardi, A

AU - Di Clemente, Francesca

AU - Basile, Eloisa

AU - Cialdella, Pio

AU - De Caterina, Alberto

AU - Porto, Italo

AU - Aurigemma, Cristina

AU - Burzotta, Francesco

AU - Niccoli, Giampaolo

AU - Trani, Carlo

AU - Rebuzzi, Antonio Giuseppe

AU - Crea, Filippo

PY - 2015

Y1 - 2015

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AB - The need of adenosine administration for the achievement of maximal hyperaemia limits the widespread application of fractional flow reserve (FFR) in the real world. We hypothesised that Pd/Pa ratio registered during submaximal reactive hyperaemia induced by conventional non-ionic radiographic contrast medium (contrast medium induced Pd/Pa ratio: CMR) can be sufficient for the assessment of physiological severity of stenosis in the vast majority of cases. The aim of the present study was to test the accuracy of CMR in comparison to FFR.

KW - fractional flow reserve

KW - stenosis

KW - fractional flow reserve

KW - stenosis

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SN - 1774-024X

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JO - EuroIntervention

JF - EuroIntervention

IS - 4

ER -

Efficacy of contrast medium induced Pd/Pa ratio in predicting functional significance of intermediate coronary artery stenosis assessed by fractional flow reserve: insights from the RINASCI study

Abstract

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