Effects of the administration of epidermal growth factor receptor specific inhibitor cetuximab, alone and in combination with cisplatin, on proliferation and apoptosis of Hep-2 laryngeal cancer cells

Francesco Bussu; Giacomo Pozzoli; Veronica Giglia; Davide Rizzo; Attilio Limongelli; Eugenio De Corso; Cristina Graziani; Gaetano Paludetti; Pierluigi Navarra; Giovanni Almadori

doi:10.1017/S002221511400190X

Effects of the administration of epidermal growth factor receptor specific inhibitor cetuximab, alone and in combination with cisplatin, on proliferation and apoptosis of Hep-2 laryngeal cancer cells

Francesco Bussu, Giacomo Pozzoli, Veronica Giglia, Davide Rizzo, Attilio Limongelli, Eugenio De Corso, Cristina Graziani, Gaetano Paludetti, Pierluigi Navarra, Giovanni Almadori

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

Epidermal growth factor receptor (EGFR) overexpression and prognostic value in head and neck squamous cell cancer is the basis for targeting by anti-EGFR antibodies, which increase the efficacy of radiotherapy. In order to evaluate the best therapeutic schedule, the effects of cetuximab (C225) on Hep-2 cell proliferation, alone and in combination with cisplatin, were studied.

Original language	English
Pages (from-to)	902-908
Number of pages	7
Journal	Journal of Laryngology and Otology
Volume	128
DOIs	https://doi.org/10.1017/S002221511400190X
Publication status	Published - 2014

Keywords

EGFR
Hep-2
Laryngeal Cancer
cisplatin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1017/S002221511400190X

Cite this

Bussu, F., Pozzoli, G., Giglia, V., Rizzo, D., Limongelli, A., De Corso, E., Graziani, C., Paludetti, G., Navarra, P., & Almadori, G. (2014). Effects of the administration of epidermal growth factor receptor specific inhibitor cetuximab, alone and in combination with cisplatin, on proliferation and apoptosis of Hep-2 laryngeal cancer cells. Journal of Laryngology and Otology, 128, 902-908. https://doi.org/10.1017/S002221511400190X

@article{60aba782fb5b43e785ee87ba460e1363,

title = "Effects of the administration of epidermal growth factor receptor specific inhibitor cetuximab, alone and in combination with cisplatin, on proliferation and apoptosis of Hep-2 laryngeal cancer cells",

abstract = "Epidermal growth factor receptor (EGFR) overexpression and prognostic value in head and neck squamous cell cancer is the basis for targeting by anti-EGFR antibodies, which increase the efficacy of radiotherapy. In order to evaluate the best therapeutic schedule, the effects of cetuximab (C225) on Hep-2 cell proliferation, alone and in combination with cisplatin, were studied.",

keywords = "EGFR, Hep-2, Laryngeal Cancer, cisplatin, EGFR, Hep-2, Laryngeal Cancer, cisplatin",

author = "Francesco Bussu and Giacomo Pozzoli and Veronica Giglia and Davide Rizzo and Attilio Limongelli and {De Corso}, Eugenio and Cristina Graziani and Gaetano Paludetti and Pierluigi Navarra and Giovanni Almadori",

year = "2014",

doi = "10.1017/S002221511400190X",

language = "English",

volume = "128",

pages = "902--908",

journal = "Journal of Laryngology and Otology",

issn = "0022-2151",

publisher = "Cambridge University Press",

}

Bussu, F, Pozzoli, G, Giglia, V, Rizzo, D, Limongelli, A, De Corso, E, Graziani, C, Paludetti, G, Navarra, P & Almadori, G 2014, 'Effects of the administration of epidermal growth factor receptor specific inhibitor cetuximab, alone and in combination with cisplatin, on proliferation and apoptosis of Hep-2 laryngeal cancer cells', Journal of Laryngology and Otology, vol. 128, pp. 902-908. https://doi.org/10.1017/S002221511400190X

Effects of the administration of epidermal growth factor receptor specific inhibitor cetuximab, alone and in combination with cisplatin, on proliferation and apoptosis of Hep-2 laryngeal cancer cells. / Bussu, Francesco; Pozzoli, Giacomo; Giglia, Veronica et al.
In: Journal of Laryngology and Otology, Vol. 128, 2014, p. 902-908.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Effects of the administration of epidermal growth factor receptor specific inhibitor cetuximab, alone and in combination with cisplatin, on proliferation and apoptosis of Hep-2 laryngeal cancer cells

AU - Bussu, Francesco

AU - Pozzoli, Giacomo

AU - Giglia, Veronica

AU - Rizzo, Davide

AU - Limongelli, Attilio

AU - De Corso, Eugenio

AU - Graziani, Cristina

AU - Paludetti, Gaetano

AU - Navarra, Pierluigi

AU - Almadori, Giovanni

PY - 2014

Y1 - 2014

N2 - Epidermal growth factor receptor (EGFR) overexpression and prognostic value in head and neck squamous cell cancer is the basis for targeting by anti-EGFR antibodies, which increase the efficacy of radiotherapy. In order to evaluate the best therapeutic schedule, the effects of cetuximab (C225) on Hep-2 cell proliferation, alone and in combination with cisplatin, were studied.

AB - Epidermal growth factor receptor (EGFR) overexpression and prognostic value in head and neck squamous cell cancer is the basis for targeting by anti-EGFR antibodies, which increase the efficacy of radiotherapy. In order to evaluate the best therapeutic schedule, the effects of cetuximab (C225) on Hep-2 cell proliferation, alone and in combination with cisplatin, were studied.

KW - EGFR

KW - Hep-2

KW - Laryngeal Cancer

KW - cisplatin

KW - EGFR

KW - Hep-2

KW - Laryngeal Cancer

KW - cisplatin

UR - http://hdl.handle.net/10807/60258

U2 - 10.1017/S002221511400190X

DO - 10.1017/S002221511400190X

M3 - Article

SN - 0022-2151

VL - 128

SP - 902

EP - 908

JO - Journal of Laryngology and Otology

JF - Journal of Laryngology and Otology

ER -

Effects of the administration of epidermal growth factor receptor specific inhibitor cetuximab, alone and in combination with cisplatin, on proliferation and apoptosis of Hep-2 laryngeal cancer cells

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this