Effects of subacute treatment with toluene on cerebrocortical alpha- and beta-adrenergic receptors in the rat. Evidence for an increased number and a reduced affinity of beta-adrenergic receptors

Maria Martire, K Fuxe, G Von Euler, Lf Agnati, T Hansson, K Andersson, Ja Gustafsson, A. Härfstrand

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Subacute treatment with toluene (80-1500 p.p.m.) produces a dose-dependent reduction of affinity and increase in density of the beta-adrenergic antagonist [3H]dihydroalprenolol binding sites in the frontoparietal cortex of the male rat, while the binding characteristics of alpha 1-adrenergic ([3H]WB 4101) and alpha 2-adrenergic ([3H]p-aminoclonidine) binding sites in the same region is unaffected by this treatment as evaluated in vitro. Therefore, it is suggested that the cortical beta-adrenergic receptors are particularly vulnerable to the action of toluene in vivo. It is speculated that as a result cortical beta-adrenergic neurotransmission may be altered following exposure to low concentrations of toluene, possibly related to the physico-chemical properties of toluene, leading to changes in membrane fluidity.
Original languageEnglish
Pages (from-to)307-311
Number of pages5
JournalActa Physiologica Scandinavica
Volume130
Publication statusPublished - 1987

Keywords

  • Animals
  • Cerebral Cortex
  • Clonidine
  • Dihydroalprenolol
  • Dioxanes
  • Male
  • Rats
  • Rats, Inbred Strains
  • Receptors, Adrenergic, alpha
  • Receptors, Adrenergic, beta
  • Toluene

Fingerprint

Dive into the research topics of 'Effects of subacute treatment with toluene on cerebrocortical alpha- and beta-adrenergic receptors in the rat. Evidence for an increased number and a reduced affinity of beta-adrenergic receptors'. Together they form a unique fingerprint.

Cite this