Effects of Sub-Acute Exposure to Rhodium (as Rh (III) chloride hydrate) on Cytokines in Female Wistar Rats

Alessandro Sgambato, Ivo Iavicoli, Luca Fontana, Veruscka Leso, Maddalena Corbi, Antonio Bergamaschi, Alessandro Marinaccio, Edward J. Calabrese

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Quantitative changes in different cytokines were determined in serum of female Wistar rats exposed to Rhodium (III) chloride hydrate to evaluate its early effects on the immune system. Findings revealed an inhibitory effect of Rh salt since each cytokine, with the exceptions of IL-1α and IL-2 levels observed at the highest doses of exposure, was reduced compared to the controls and interestingly, the lowest doses induced the greatest inhibition. This generalized decrease of cytokine levels was not related to a specific cytokine pathway, and may suggest an anti-inflammatory role of Rh salt.
Original languageEnglish
Pages (from-to)686-692
Number of pages7
JournalBulletin of Environmental Contamination and Toxicology
Volume89
DOIs
Publication statusPublished - 2012

Keywords

  • rhodium

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