Effects of ghrelin administration on endocrine and metabolic parameters in obese women with polycystic ovary syndrome

Antonio Mancini, Antonio Lanzone, Alfredo Pontecorvi, Alessandra Fusco, Antonio Bianchi, Domenico Milardi, Antonella Giampietro, Daniela Romualdi, Maurizio Guido, Laura De Marinis Grasso, V Cimino, Teresa Porcelli

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The novel peptide ghrelin displays multiple endocrine and non-endocrine actions. Its strong GH-releasing activity in humans has long been recognized. However, in obesity, ghrelin administration induces a blunted GH secretion, enhances glucose and reduces insulin levels. The effects of ghrelin administration have not been investigated in polycystic ovary syndrome (PCOS), which can be associated with obesity, hyperinsulinism, and GH hyposecretion. Leptin is a mediator for energy balance opposed to ghrelin; both of them are supposed to act as regulators of reproductive functions.
Original languageEnglish
Pages (from-to)948-956
Number of pages9
JournalJournal of Endocrinological Investigation
Volume30
Publication statusPublished - 2007

Keywords

  • Adult
  • Blood Glucose
  • Fatty Acids, Nonesterified
  • Female
  • Ghrelin
  • Growth Hormone
  • Humans
  • Insulin
  • Leptin
  • Obesity
  • Polycystic Ovary Syndrome
  • Prolactin
  • Thyrotropin

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