EFFECTS OF GEMFIBROZIL ON THE OXYGEN-TRANSPORT PROPERTIES OF ERYTHROCYTES

Roberto Scatena, Giuseppina Nocca, Silvia Baroni, Cecilia Zuppi, Massimo Castagnola, Bruno Giardina, I Messana, P Desole

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

1 In the present study we have investigated the effects of the relatively low plasma concentrations of gemfibrozil (GFZ) found in clinical practice on the oxygen dissociation curve (ODC) of erythrocytes. 2 ODCs were measured at 30 degrees C and 37 degrees C and at pH 7.4: a) both on HbA solution and erythrocytes incubated in vitro with gemfibrozil and clofibric acid; b) on erythrocytes from healthy volunteers treated with a single oral dose of gemfibrozil. 3 These experiments showed a significant drug-induced shift of the ODC towards lower O-2, affinity values without any significant modification of metabolic parameters of erythrocytes such as intracellular pH and intraerythrocytic levels of ATP and DPG. 4 In our experimental conditions gemfibrozil appears to lower both in vitro and in vivo, the partial pressure of oxygen required to give 50% of the haemes saturated with oxygen (P-50) Of erythrocytes from the control value of 24 +/- 0.5 mm Hg to 29 +/- 0.5 mm Hg (mean +/- s.d.; P < 0.02 by ANOVA). 5 These data clearly indicate that therapeutic doses of gemfibrozil may influence the oxygen transport properties of red cells. This effect could have relevant pharmacological and toxicological implications.
Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalBRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Volume39
Publication statusPublished - 1995

Keywords

  • ERYTHROCYTES

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