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Effect of vagal nerve stimulation on systemic inflammation and cardiac autonomic function in patients with refractory epilepsy

  • Lucy Barone
  • , Gabriella Colicchio
  • , Domenico Policicchio
  • , Francesca Di Clemente
  • , Antonio Di Monaco
  • , Mario Meglio
  • , Gaetano Antonio Lanza
  • , Filippo Crea

Research output: Contribution to journalArticle

Abstract

Recent data suggest that vagus nerve stimulation (VNS) can inhibit cytokine release by inflammatory cells. Accordingly, an association between impaired cardiac parasympathetic function, as assessed by heart rate variability (HRV), and increased markers of inflammation has recently been reported. In this study we assessed the effect of direct left VNS on inflammatory markers and HRV in patients with refractory epilepsy.
Original languageEnglish
Pages (from-to)331-336
Number of pages6
JournalNeuroImmunoModulation
Volume14
Issue number6
DOIs
Publication statusPublished - 2007

Keywords

  • Adolescent
  • Adult
  • Aged
  • Ambulatory
  • Autonomic Nervous System
  • C-Reactive Protein
  • Child
  • Electric Stimulation Therapy
  • Electrocardiography
  • Epilepsy
  • Female
  • Heart
  • Heart Rate
  • Humans
  • Inflammation
  • Interleukin-6
  • Male
  • Neuroimmunomodulation
  • Tumor Necrosis Factor-alpha
  • Vagus Nerve

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