Effect of oral sebacic Acid on postprandial glycemia, insulinemia, and glucose rate of appearance in type 2 diabetes

Geltrude Mingrone, Amerigo Iaconelli, Angela Maria Rita Favuzzi, Amalia Gastaldelli, Christophe Binnert, Katherine Macé

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Dicarboxylic acids are natural products with the potential of being an alternate dietary source of energy. We aimed to evaluate the effect of sebacic acid (a 10-carbon dicarboxylic acid; C10) ingestion on postprandial glycemia and glucose rate of appearance (Ra) in healthy and type 2 diabetic subjects. Furthermore, the effect of C10 on insulin-mediated glucose uptake and on GLUT4 expression was assessed in L6 muscle cells in vitro.
Original languageEnglish
Pages (from-to)2327-2332
Number of pages6
JournalDiabetes Care
Volume33
DOIs
Publication statusPublished - 2010

Keywords

  • Absorptiometry, Photon
  • Animals
  • Biological Transport
  • Blood Glucose
  • Blotting, Western
  • Body Composition
  • C-Peptide
  • Cell Line
  • Decanoic Acids
  • Diabetes Mellitus, Type 2
  • Dicarboxylic Acids
  • Female
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Immunoprecipitation
  • Insulin
  • Male
  • Middle Aged
  • Postprandial Period
  • Rats

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