Effect of ketorolac, ketoprofen and nefopam on platelet function

Pl Dordoni, M Della Ventura, A Stefanelli, E Iannace, P Paparella, Bianca Rocca, F. Accorra

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Ketorolac, ketoprofen and nefopam are often used in the treatment of postoperative pain. While nefopam is a non-narcotic, non-opioid central analgesic agent, ketorolac and ketoprofen are non-steroidal anti-inflammatory drugs, which, due to their prostaglandin-synthetase inhibiting activity, have antiplatelet effects. In this study we investigated the effect of ketorolac, ketoprofen and nefopam on platelet function by performing bleeding time and in vitro platelet aggregation in 30 healthy volunteers (10 for each treatment) before and 3 h after drug administration. Nefopam did not affect bleeding time and platelet aggregation, while ketorolac and ketoprofen significantly prolonged bleeding time without significantly inhibiting platelet aggregation in response to adenosine diphosphate. The prolongation of bleeding time observed after ketorolac and ketoprofen may have clinical relevance and suggests that nefopam could be more safely administered for the treatment of postoperative pain, especially in patients with haemostatic defects or after high bleeding risk surgery.
Original languageEnglish
Pages (from-to)1046-1049
Number of pages4
JournalAnaesthesia
Volume49
Publication statusPublished - 1994

Keywords

  • Bleeding Time
  • Blood Platelets
  • Cells, Cultured
  • Female
  • Humans
  • Ketoprofen
  • Ketorolac
  • Nefopam
  • Platelet Aggregation
  • Platelet Aggregation Inhibitors
  • Tolmetin

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