Effect of aerosolized colistin as adjunctive treatment on the outcomes of microbiologically documented ventilator-associated pneumonia caused by colistin-only susceptible gram-negative bacteria

Mario Tumbarello; Gennaro De Pascale; Enrico Maria Trecarichi; Salvatore De Martino; Giuseppe Bello; Riccardo Maviglia; Teresa Spanu; Massimo Antonelli

doi:10.1378/chest.13-1018

Effect of aerosolized colistin as adjunctive treatment on the outcomes of microbiologically documented ventilator-associated pneumonia caused by colistin-only susceptible gram-negative bacteria

Mario Tumbarello, Gennaro De Pascale, Enrico Maria Trecarichi, Salvatore De Martino, Giuseppe Bello, Riccardo Maviglia, Teresa Spanu, Massimo Antonelli

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Abstract

The increasing frequency of ventilator-associated pneumonia (VAP) caused by colistin-only susceptible (COS) gram-negative bacteria (GNB) is of great concern. Adjunctive aerosolized (AS) colistin can reportedly increase alveolar levels of the drug without increasing systemic toxicity. Good clinical results have been obtained in patients with cystic fibrosis, but conflicting data have been reported in patients with VAP.

Original language	English
Pages (from-to)	1768-1775
Number of pages	8
Journal	Chest
Volume	144
DOIs	https://doi.org/10.1378/chest.13-1018
Publication status	Published - 2013

Keywords

VAP
colistin

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10.1378/chest.13-1018

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Tumbarello, M., De Pascale, G., Trecarichi, E. M., De Martino, S., Bello, G., Maviglia, R., Spanu, T., & Antonelli, M. (2013). Effect of aerosolized colistin as adjunctive treatment on the outcomes of microbiologically documented ventilator-associated pneumonia caused by colistin-only susceptible gram-negative bacteria. Chest, 144, 1768-1775. https://doi.org/10.1378/chest.13-1018

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title = "Effect of aerosolized colistin as adjunctive treatment on the outcomes of microbiologically documented ventilator-associated pneumonia caused by colistin-only susceptible gram-negative bacteria",

abstract = "The increasing frequency of ventilator-associated pneumonia (VAP) caused by colistin-only susceptible (COS) gram-negative bacteria (GNB) is of great concern. Adjunctive aerosolized (AS) colistin can reportedly increase alveolar levels of the drug without increasing systemic toxicity. Good clinical results have been obtained in patients with cystic fibrosis, but conflicting data have been reported in patients with VAP.",

keywords = "VAP, colistin, VAP, colistin",

author = "Mario Tumbarello and {De Pascale}, Gennaro and Trecarichi, {Enrico Maria} and {De Martino}, Salvatore and Giuseppe Bello and Riccardo Maviglia and Teresa Spanu and Massimo Antonelli",

year = "2013",

doi = "10.1378/chest.13-1018",

language = "English",

volume = "144",

pages = "1768--1775",

journal = "Chest",

issn = "0012-3692",

publisher = "American College of Chest Physicians:3300 Dundee Road:Northbrook, IL 60062:(800)343-2227, (847)498-1400, EMAIL: subscriptions@chestnet.org, INTERNET: http://www.chestnet.org, Fax: (847)498-5460",

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Tumbarello, M, De Pascale, G, Trecarichi, EM, De Martino, S, Bello, G, Maviglia, R, Spanu, T & Antonelli, M 2013, 'Effect of aerosolized colistin as adjunctive treatment on the outcomes of microbiologically documented ventilator-associated pneumonia caused by colistin-only susceptible gram-negative bacteria', Chest, vol. 144, pp. 1768-1775. https://doi.org/10.1378/chest.13-1018

TY - JOUR

T1 - Effect of aerosolized colistin as adjunctive treatment on the outcomes of microbiologically documented ventilator-associated pneumonia caused by colistin-only susceptible gram-negative bacteria

AU - Tumbarello, Mario

AU - De Pascale, Gennaro

AU - Trecarichi, Enrico Maria

AU - De Martino, Salvatore

AU - Bello, Giuseppe

AU - Maviglia, Riccardo

AU - Spanu, Teresa

AU - Antonelli, Massimo

PY - 2013

Y1 - 2013

N2 - The increasing frequency of ventilator-associated pneumonia (VAP) caused by colistin-only susceptible (COS) gram-negative bacteria (GNB) is of great concern. Adjunctive aerosolized (AS) colistin can reportedly increase alveolar levels of the drug without increasing systemic toxicity. Good clinical results have been obtained in patients with cystic fibrosis, but conflicting data have been reported in patients with VAP.

AB - The increasing frequency of ventilator-associated pneumonia (VAP) caused by colistin-only susceptible (COS) gram-negative bacteria (GNB) is of great concern. Adjunctive aerosolized (AS) colistin can reportedly increase alveolar levels of the drug without increasing systemic toxicity. Good clinical results have been obtained in patients with cystic fibrosis, but conflicting data have been reported in patients with VAP.

KW - VAP

KW - colistin

KW - VAP

KW - colistin

UR - http://hdl.handle.net/10807/53443

U2 - 10.1378/chest.13-1018

DO - 10.1378/chest.13-1018

M3 - Article

VL - 144

SP - 1768

EP - 1775

JO - Chest

JF - Chest

SN - 0012-3692

ER -

Effect of aerosolized colistin as adjunctive treatment on the outcomes of microbiologically documented ventilator-associated pneumonia caused by colistin-only susceptible gram-negative bacteria

Abstract

Keywords

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