Effect of aerosolized colistin as adjunctive treatment on the outcomes of microbiologically documented ventilator-associated pneumonia caused by colistin-only susceptible gram-negative bacteria

Teresa Spanu, Massimo Antonelli, Mario Tumbarello

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

The increasing frequency of ventilator-associated pneumonia (VAP) caused by colistin-only susceptible (COS) gram-negative bacteria (GNB) is of great concern. Adjunctive aerosolized (AS) colistin can reportedly increase alveolar levels of the drug without increasing systemic toxicity. Good clinical results have been obtained in patients with cystic fibrosis, but conflicting data have been reported in patients with VAP.
Original languageEnglish
Pages (from-to)1768-1775
Number of pages8
JournalChest
Volume144
DOIs
Publication statusPublished - 2013

Keywords

  • VAP
  • colistin

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