Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease

Antonio Daniele, Carlo Masullo, Guido D'Onofrio, Alessandra Bizzarro, G. D’Onofrio, A. Bizzarro, F. Mangialasche, L. Cascavilla, F. Paris, M. G. Matera, Andrea Pilotto, P. Mecocci, B. Dallapiccola, D. Seripa

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

To evaluate the influence of the single nucleotide polymorphism rs1080985 in the cytochrome P450 2D6 (CYP2D6) gene on the efficacy of donepezil in patients with mild to moderate Alzheimer disease (AD).
Original languageEnglish
Pages (from-to)761-767
Number of pages7
JournalNeurology
Volume73
DOIs
Publication statusPublished - 2009

Keywords

  • Aged
  • Aged, 80 and over
  • Alleles
  • Alzheimer Disease
  • Apolipoproteins E
  • Cohort Studies
  • Cytochrome P-450 CYP2D6
  • Female
  • Follow-Up Studies
  • Gene Frequency
  • Genotype
  • Humans
  • Indans
  • Male
  • Piperidines
  • Polymorphism, Single Nucleotide
  • Prospective Studies

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