Ecofriendly synergists for insecticide formulations (EcoSyn)

Valerio Borzatta, Francesco Tozzi, Mark Johnston, Alan Dewar, Chris Bass, Lin Field, Dalibor Titera, Mark Kamler, Michela Panini, Emanuele Mazzoni, Graham Moores

Research output: Chapter in Book/Report/Conference proceedingConference contribution


EcoSyn consists of a consortium of experts to optimise the use of synergists in agriculture and public health by elucidating the relationship between synergist chemical structure and activity on a variety of target insect metabolic enzymes: this will enhance the efficacy of insecticides against resistant and susceptible pest insects in both laboratory and field environments. Repeated use of synthetic insecticides has resulted in the development of insecticide resistance; inhibition of insect defence enzymes by synergists would allow increased kill of resistant pests and control of susceptible pests with reduced insecticidal rates. EcoSyn has characterised interactions of novel synergists based on PBO (piperonyl butoxide) against known resistance-conferring P450/esterase proteins by both in vitro and in vivo assays. Candidate synergists have also been tested against pollinators and in long-term selection experiments to investigate changes in insect pest transcriptome
Original languageEnglish
Title of host publicationResistance 2015 - Abstract Book
Number of pages1
Publication statusPublished - 2015
EventResistance 2015 - Rothamsted Research, Harpenden (UK)
Duration: 14 Sept 201516 Sept 2015


ConferenceResistance 2015
CityRothamsted Research, Harpenden (UK)


  • PBO
  • synergists


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