Distinct impact of vitamin D insufficiency on calcitriol levels in chronic renal failure and renal transplant patients: a role for FGF23

Franco Citterio, S Mazzaferro, M Pasquali, F Pugliese, A Gargiulo, S Rotondi, L Tartaglione, C Conte, G Pirrò, F. Taggi

Research output: Contribution to journalArticle

Abstract

Vitamin D insufficiency contributes to calcitriol (1,25D) reduction in chronic kidney disease (CKD). Since CKD patients on conservative therapy (CRF) mostly develop, whereas transplant (TX) patients possibly recover from, secondary hyperparathyroidism (SH), we hypothesized a different efficiency of vitamin D hydroxylation in these 2 clinical conditions.
Original languageEnglish
Pages (from-to)1108-1118
Number of pages11
JournalJN. JOURNAL OF NEPHROLOGY
Volume25
DOIs
Publication statusPublished - 2012

Keywords

  • Adult
  • Aged
  • Alkaline Phosphatase
  • Biological Markers
  • Calcitriol
  • Calcium
  • Chi-Square Distribution
  • Dietary Supplements
  • Female
  • Fibroblast Growth Factors
  • Glomerular Filtration Rate
  • Humans
  • Hydroxylation
  • Kidney Failure, Chronic
  • Kidney Transplantation
  • Male
  • Middle Aged
  • Parathyroid Hormone
  • Phosphates
  • Regression Analysis
  • Vitamin D
  • Vitamin D Deficiency

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