Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis

Valentina Damato, Amelia Evoli, Emanuela Bartoccioni, Tanel Punga, Marta Lewandowska, Anna Rostedt Punga

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Myasthenia gravis (MG) patients with antibodies against the muscle specific tyrosine kinase (MuSK +) have predominantly involvement of cranio-bulbar muscles and do not display thymus pathology, as do acetylcholine receptor antibody seropositive (AChR +) MG patients. In search of novel biomarkers for MuSK + MG, we evaluated circulating serum microRNAs. Four analyzed microRNAs were specifically elevated in MuSK + MG patient serum samples: let-7a-5p, let-7f-5p, miR-151a-3p and miR-423-5p. The circulating microRNA profile in MuSK. + MG differs from the profile previously observed in the serum of AChR + MG, thus indicating the etiological difference between these two entities. We propose that the identified microRNAs could serve as potential serum biomarkers for MuSK + MG.
Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalJournal of Neuroimmunology
Volume292
DOIs
Publication statusPublished - 2016

Keywords

  • Adult
  • Aged, 80 and over
  • Anti-Inflammatory Agents
  • Autoantibodies
  • Biomarker
  • Case-Control Studies
  • Electromyography
  • Female
  • Humans
  • Immunology
  • Immunology and Allergy
  • Let-7
  • MG
  • Male
  • MicroRNA
  • MicroRNAs
  • Middle Aged
  • MuSK
  • Muscle specific tyrosine kinase
  • Myasthenia Gravis
  • Myasthenia gravis
  • Neurology
  • Neurology (clinical)
  • Prednisone
  • RNA, Messenger
  • ROC Curve
  • Receptors, Cholinergic
  • Young Adult

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