Disease-specific and general health-related quality of life in newly diagnosed prostate cancer patients: The Pros-IT CNR study

Pierfrancesco Bassi, Angelo Porreca, Anna Rita Alitto, Patrizia Fiorella Bove, Rolando Maria D'Angelillo, Andrea Guarneri, Giovanna Mantini, Marianna Noale, Walter Artibani, Filippo Bertoni, Sergio Bracarda, Giario Natale Conti, Renzo Corvò, Mauro Gacci, Pierpaolo Graziotti, Stefano Maria Magrini, Vincenzo Mirone, Rodolfo Montironi, Giovanni Muto, Stefano PecoraroUmberto Ricardi, Elvio Russi, Andrea Tubaro, Vittorina Zagonel, Gaetano Crepaldi, Stefania Maggi, Enrica Ambrosi, Alessandro Antonelli, Cynthia Aristei, Michele Barbieri, Franco Bardari, Lilia Bardoscia, Salvina Barra, Sara Bartoncini, Umberto Basso, Carlotta Becherini, Rita Bellavita, Franco Bergamaschi, Stefania Berlingheri, Alfredo Berruti, Marco Borghesi, Roberto Bortolus, Valentina Borzillo, Davide Bosetti, Giuseppe Bove, Pierluigi Bove, Brausi Maurizio, Bruni Alessio, Bruno Giorgio, Brunocilla Eugenio, Buffoli Alberto, Buglione Michela, Buttigliero Consuelo, Cacciamani Giovanni, Caldiroli Michela, Cardo Giuseppe, Carmignani Giorgio, Carrieri Giuseppe, Castelli Emanuele, Castrezzati Elisabetta, Catalano Gianpiero, Cattarino Susanna, Francesco Catucci, Cavallini Francolini Dario, Ceccarini Ofelia, Celia Antonio, Chiancone Francesco, Chini Tommaso, Cianci Claudia, Cisternino Antonio, Collura Devis, Corbella Franco, Corinti Matteo, Corsi Paolo, Cortese Fiorenza, Corti Luigi, De Nunzio Cosimo, Olga Cristiano, Rolando M. D’Angelillo, Luigi Da Pozzo, Daniele D’Agostino, Carolina D’Elia, Matteo Dandrea, Michele De Angelis, Paolo De Angelis, Ottavio De Cobelli, Bernardino De Concilio, Antonello De Lisa, Stefano De Luca, Agostina De Stefani, Chiara Lucrezia Deantoni, Esposti Claudio Degli, Anna Destito, Beatrice Detti, Nadia Di Muzio, Andrea Di Stasio, Calogero Di Stefano, Danilo Di Trapani, Giuseppe Difino, Sara Falivene, Giuseppe Farullo, Paolo Fedelini, Ilaria Ferrari, Francesco Ferrau, Matteo Ferro, Andrei Fodor, Francesco Fontanta, Francesco Francesca, Giulio Francolini, Paolo Frata, Giovanni Frezza, Pietro Gabriele, Maria Galeandro, Elisabetta Garibaldi, Pietro Giovanni Gennari, Alessandro Gentilucci, Alessandro Giacobbe, Laura Giussani, Giuseppe Giusti, Paolo Gontero, Alessia Guarneri, Cesare Guida, Alberto Gurioli, Dorijan Huqi, Ciro Imbimbo, Gianluca Ingrosso, Cinzia Iotti, Corrado Italia, Pierdaniele La Mattina, Enza Lamanna, Luciana Lastrucci, Grazia Lazzari, Fabiola Liberale, Giovanni Liguori, Roberto Lisi, Frank Lohr, Riccardo Lombardo, Jon Aj Lovisolo, Giuseppe Mario Ludovico, Nicola Macchione, Francesca Maggio, Michele Malizia, Gianluca Manasse, Giovanni Mandoliti, Luigi Marafioti, Luisa Marciello, Alberto Mario Marconi, Antonietta Martilotta, Salvino Marzano, Stefano Masciullo, Gloria Maso, Adele Massenzo, Ercole Mazzeo, Luigi Mearini, Serena Medoro, Rosa Molè, Giorgio Monesi, Emanuele Montanari, Franco Montefiore, Giampaolo Montesi, Giuseppe Morgia, Gregorio Moro, Giorgio Muscas, Daniela Musio, Paolo Muto, Giovanni Muzzonigro, Giorgio Napodano, Carlo Luigi Augusto Negro, Mattia Nidini, Maria Ntreta, Marco Orsatti, Carmela Palazzolo, Isabella Palumbo, Alessandro Parisi, Paolo Parma, Nicola Pavan, Martina Pericolini, Francesco Pinto, Antonio Pistone, Valerio Pizzuti, Angelo Platania, Caterina Polli, Giorgio Pomara, Elisabetta Ponti, Antonio Benito Porcaro, Francesco Porpiglia, Dario Pugliese, Armin Pycha, Giuseppe Raguso, Andrea Rampini, Donato Franco Randone, Valentina Roboldi, Marco Roscigno, Maria Paola Ruggieri, Giuseppe Ruoppo, Roberto Sanseverino, Anna Santacaterina, Michele Santarsieri, Riccardo Santoni, Sarah Scagliarini, Giorgio Vittorio Scagliotti, Mauro Scanzi, Marcello Scarcia, Riccardo Schiavina, Alessandro Sciarra, Carmine Sciorio, Tindaro Scolaro, Salvatore Scuzzarella, Oscar Selvaggio, Armando Serao, Sergio Serni, Marco Andrea Signor, Mauro Silvani, Giovanni Silvano, Franco Silvestris, Claudio Simeone, Valeria Simone, Girolamo Spagnoletti, Matteo Giulio Spinelli, Luigi Squillace, Vincenzo Tombolini, Mariastella Toninelli, Luca Triggiani, Alberto Trinchieri, Luca Eolo Trodella, Lucio Trodella, Carlo Trombetta, Lidia Tronnolone, Marcello Tucci, Daniele Urzì, Riccardo Valdagni, Maurizio Valeriani, Maurizio Vanoli, Elisabetta Vitali, Alessandro Volpe, Stefano Zaramella, Guglielmo Zeccolini, Giampaolo Zini

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: The National Research Council (CNR) prostate cancer monitoring project in Italy (Pros-IT CNR) is an observational, prospective, ongoing, multicentre study aiming to monitor a sample of Italian males diagnosed as new cases of prostate cancer. The present study aims to present data on the quality of life at time prostate cancer is diagnosed. Methods: One thousand seven hundred five patients were enrolled. Quality of life is evaluated at the time cancer was diagnosed and at subsequent assessments via the Italian version of the University of California Los Angeles-Prostate Cancer Index (UCLA-PCI) and the Short Form Health Survey (SF-12). Results: At diagnosis, lower scores on the physical component of the SF-12 were associated to older ages, obesity and the presence of 3+ moderate/severe comorbidities. Lower scores on the mental component were associated to younger ages, the presence of 3+ moderate/severe comorbidities and a T-score higher than one. Urinary and bowel functions according to UCLA-PCI were generally good. Almost 5% of the sample reported using at least one safety pad daily to control urinary loss; less than 3% reported moderate/severe problems attributable to bowel functions, and sexual function was a moderate/severe problem for 26.7%. Diabetes, 3+ moderate/severe comorbidities, T2 or T3-T4 categories and a Gleason score of eight or more were significantly associated with lower sexual function scores at diagnosis. Conclusions: Data collected by the Pros-IT CNR study have clarified the baseline status of newly diagnosed prostate cancer patients. A comprehensive assessment of quality of life will allow to objectively evaluate outcomes of different profile of care.
Original languageEnglish
Pages (from-to)122-N/A
JournalHealth and Quality of Life Outcomes
Volume16
DOIs
Publication statusPublished - 2018

Keywords

  • Activities of Daily Living
  • Age Factors
  • Aged
  • Diagnosis
  • Health Surveys
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Neoadjuvant Therapy
  • Percutaneous Coronary Intervention
  • Pros-IT CNR study
  • Prospective Studies
  • Prostate cancer
  • Prostatic Neoplasms
  • Quality of Life
  • Quality of life
  • Regression Analysis
  • Severity of Illness Index

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