Abstract
Molecular-based carbapenem resistance testing in Gram-negative bacterial bloodstream infections (BSIs) is currently limited because of the reliance on positive blood culture (BC) samples. The T2Resistance™ panel may now allow the detection of carbapenemase-and other β-lactamase encoding genes directly from blood samples. We detected carbapenem resistance genes in 11 (84.6%) of 13 samples from patients with BC-documented BSIs (10 caused by KPC-producing Klebsiella pneumoniae and 1 caused by VIM/CMY-producing Citrobacter freundii). Two samples that tested negative for carbapenem resistance genes were from patients with BC-documented BSIs caused by KPC-producing K. pneumoniae who were receiving effective antibiotic therapy. In conclusion, our findings suggest that the T2Resistance™ panel can be a reliable tool for diagnosing carbapenem-resistant Gram-negative bacterial BSIs.
| Original language | English |
|---|---|
| Pages (from-to) | 950-N/A |
| Journal | Antibiotics |
| Volume | 10 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2021 |
All Science Journal Classification (ASJC) codes
- Microbiology
- Biochemistry
- General Pharmacology, Toxicology and Pharmaceutics
- Microbiology (medical)
- Infectious Diseases
- Pharmacology (medical)
Keywords
- Antimicrobial resistance
- Blood sample
- Bloodstream infection
- Direct detection
- KPC carbapenemase
- Magnetic resonance
- T2Resistance panel
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