Diagnosing multiple drug hypersensitivity in children

Antonino Romano, Marina Atanasković-Marković, Francesco Gaeta, Marija Gavrović-Jankulović, Tanja Čirković Veličković, Rocco Luigi Valluzzi

Research output: Contribution to journalArticle

24 Citations (Scopus)


Multiple drug hypersensitivity (MDH) has been defined as a hypersensitivity to two or more chemically different drugs. Two types of MDH have been reported: the first one, which develops to different drugs administered simultaneously and the second type, in which sensitizations develop sequentially. In children, studies which diagnose MDH on the basis of positive allergologic tests to 2 or more chemically different drugs are lacking.
Original languageEnglish
Pages (from-to)785-791
Number of pages7
JournalPediatric Allergy and Immunology
Publication statusPublished - 2012


  • Adolescent
  • Anti-Bacterial Agents
  • Anticonvulsants
  • Cephalosporins
  • Child
  • Child, Preschool
  • Drug Hypersensitivity
  • Female
  • Humans
  • Ibuprofen
  • Immunoglobulin E
  • Male
  • Patch Tests
  • Prospective Studies
  • Skin Tests
  • beta-Lactams


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