Determinants of Quality of Life in High-Dose Benzodiazepine Misusers.

Giovanni Addolorato, Antonio Mirijello, Stefano Tamburin, Angela Federico, Marco Faccini, Rebecca Casari, Laura Morbioli, Valentina Sartore, Fabio Lugoboni

Research output: Contribution to journalArticle

17 Citations (Scopus)


Benzodiazepines (BZDs) are among the most widely prescribed drugs in developed countries, but they have a high potential for tolerance, dependence and misuse. High-dose BZD misuse represents an emerging addiction phenomenon, but data on quality of life (QoL) in high-dose BZD misusers are scant. This study aimed to explore QoL in high-dose BZD misuse. We recruited 267 high-dose BZD misusers, compared the QoL scores in those who took BZD only to poly-drug misusers, and explored the role of demographic and clinical covariates through multivariable analysis. Our data confirmed worse QoL in high-dose BZD misusers and showed that (a) QoL scores were not negatively influenced by the misuse of alcohol or other drugs, or by coexisting psychiatric disorders; (b) demographic variables turned out to be the most significant predictors of QoL scores; (c) BZD intake significantly and negatively influenced QoL. Physical and psychological dimensions of QoL are significantly lower in high-dose BZD misusers with no significant effect of comorbidities. Our data suggest that the main reason for poor QoL in these patients is high-dose BZD intake per se. QoL should be considered among outcome measures in these patients.
Original languageEnglish
Pages (from-to)38-38
Number of pages1
JournalInternational Journal of Environmental Research and Public Health
Publication statusPublished - 2017


  • benzodiazepine

Fingerprint Dive into the research topics of 'Determinants of Quality of Life in High-Dose Benzodiazepine Misusers.'. Together they form a unique fingerprint.

Cite this