Detection of Gibberellin-Regulated Protein (Peamaclein) Sensitization among Italian Cypress Pollen-Sensitized Patients

R Asero; S Abbadessa; A Aruanno; G Barilaro; C Barzaghi; D Bignardi; M B Bilò; M Borro; Marco Torkel Bresciani; M Busa; F Buzzulini; C Cavaliere; L Cecchi; A Ciccarelli; G Cortellini; F Cucinelli; G Deleonardi; F Emiliani; A Farsi; E Ferrarini; M Franchini; A Ingrassia; D Lippolis; L Losappio; A M Marra; M Martini; S Masieri; Michele Mauro; M Mazzolini; L Muratore; F Murzilli; Eleonora Nucera; E A Pastorello; E Pinter; B R Polillo; V Pravettoni; O Quercia; Angela Rizzi; M Russello; C Sacerdoti; E Scala; G Scala; A Scarpa; J Schroeder; G G Uasuf; D Villalta; B Yang; G Mistrello; S Amato; J Lidholm

doi:10.18176/jiaci.0542

Detection of Gibberellin-Regulated Protein (Peamaclein) Sensitization among Italian Cypress Pollen-Sensitized Patients

R Asero, S Abbadessa, A Aruanno, G Barilaro, C Barzaghi, D Bignardi, M B Bilò, M Borro, Marco Torkel Bresciani, M Busa, F Buzzulini, C Cavaliere, L Cecchi, A Ciccarelli, G Cortellini, F Cucinelli, G Deleonardi, F Emiliani, A Farsi, E FerrariniM Franchini, A Ingrassia, D Lippolis, L Losappio, A M Marra, M Martini, S Masieri, Michele Mauro, M Mazzolini, L Muratore, F Murzilli, Eleonora Nucera, E A Pastorello, E Pinter, B R Polillo, V Pravettoni, O Quercia, Angela Rizzi, M Russello, C Sacerdoti, E Scala, G Scala, A Scarpa, J Schroeder, G G Uasuf, D Villalta, B Yang, G Mistrello, S Amato, J Lidholm

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Abstract

Background: Peach gibberellin-regulated protein (peamaclein) has recently emerged as a relevant food allergen in cypress pollen-hypersensitive patients. Objective: We looked for mono-sensitization to peamaclein among Italian cypress-pollen allergic patients. Material and methods: 835 cypress pollen hypersensitive patients from 28 Italian allergy centers under went thorough interview for food-allergic reactions, and SPT with a commercial peach extracts containing peamaclein. In peach reactors, IgE to rPru p 3 was measured, and those scoring negative were enrolled as potentially mono-sensitized to peamaclein. IgE reactivity to rPru p 7 was evaluated by immunoblot and by an experimental ImmunoCAP with rPru p 7. Results: Peach SPT scored positive in 163 (19.5%) patients but 127 (77,9%) were excluded because Pru p 3 reactors. Twenty-four (14,7%, corresponding to 2.8% of the entire study population) were considered as potentially mono-sensitized to peamaclein. Their distribution did not show any geographic preference. Seventeen/24 (70,8%) had a history of food allergy, in most cases (n=15) to peach. Other offending foods included other Rosaceae, citrus fruits, fig, melon, tree nuts, and kiwi. On peach immunoblot, only 3/18 putative peamaclein allergic subjects reacted to a band at about 7kDa; 4 other patients reacted at about 50-60 kDa. Ten/18 (56%) scored positive for Pru p 7 on ImmunoCAP. Conclusion: Peamaclein allergy and sensitization prevalence seem rare in Italy. Most patients react to peach, albeit other Rosaceae fruits and several citrus fruits may also act as offending foods. Peach and cypress pollen probably share also cross-reacting allergens other than peamaclein.

Original language	English
Pages (from-to)	N/A-N/A
Journal	JOURNAL OF INVESTIGATIONAL ALLERGOLOGY & CLINICAL IMMUNOLOGY
Volume	32
DOIs	https://doi.org/10.18176/jiaci.0542
Publication status	Published - 2020

Keywords

Cypress pollen allergy
Food allergy
Peach
Peamaclein
Pollen food syndrome

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10.18176/jiaci.0542

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Asero, R., Abbadessa, S., Aruanno, A., Barilaro, G., Barzaghi, C., Bignardi, D., Bilò, M. B., Borro, M., Bresciani, M. T., Busa, M., Buzzulini, F., Cavaliere, C., Cecchi, L., Ciccarelli, A., Cortellini, G., Cucinelli, F., Deleonardi, G., Emiliani, F., Farsi, A., ... Lidholm, J. (2020). Detection of Gibberellin-Regulated Protein (Peamaclein) Sensitization among Italian Cypress Pollen-Sensitized Patients. JOURNAL OF INVESTIGATIONAL ALLERGOLOGY & CLINICAL IMMUNOLOGY, 32, N/A-N/A. https://doi.org/10.18176/jiaci.0542

@article{070fc657d8e546928fc268d852c80387,

title = "Detection of Gibberellin-Regulated Protein (Peamaclein) Sensitization among Italian Cypress Pollen-Sensitized Patients",

abstract = "Background: Peach gibberellin-regulated protein (peamaclein) has recently emerged as a relevant food allergen in cypress pollen-hypersensitive patients. Objective: We looked for mono-sensitization to peamaclein among Italian cypress-pollen allergic patients. Material and methods: 835 cypress pollen hypersensitive patients from 28 Italian allergy centers under went thorough interview for food-allergic reactions, and SPT with a commercial peach extracts containing peamaclein. In peach reactors, IgE to rPru p 3 was measured, and those scoring negative were enrolled as potentially mono-sensitized to peamaclein. IgE reactivity to rPru p 7 was evaluated by immunoblot and by an experimental ImmunoCAP with rPru p 7. Results: Peach SPT scored positive in 163 (19.5%) patients but 127 (77,9%) were excluded because Pru p 3 reactors. Twenty-four (14,7%, corresponding to 2.8% of the entire study population) were considered as potentially mono-sensitized to peamaclein. Their distribution did not show any geographic preference. Seventeen/24 (70,8%) had a history of food allergy, in most cases (n=15) to peach. Other offending foods included other Rosaceae, citrus fruits, fig, melon, tree nuts, and kiwi. On peach immunoblot, only 3/18 putative peamaclein allergic subjects reacted to a band at about 7kDa; 4 other patients reacted at about 50-60 kDa. Ten/18 (56%) scored positive for Pru p 7 on ImmunoCAP. Conclusion: Peamaclein allergy and sensitization prevalence seem rare in Italy. Most patients react to peach, albeit other Rosaceae fruits and several citrus fruits may also act as offending foods. Peach and cypress pollen probably share also cross-reacting allergens other than peamaclein.",

keywords = "Cypress pollen allergy, Food allergy, Peach, Peamaclein, Pollen food syndrome, Cypress pollen allergy, Food allergy, Peach, Peamaclein, Pollen food syndrome",

author = "R Asero and S Abbadessa and A Aruanno and G Barilaro and C Barzaghi and D Bignardi and Bil{\`o}, {M B} and M Borro and Bresciani, {Marco Torkel} and M Busa and F Buzzulini and C Cavaliere and L Cecchi and A Ciccarelli and G Cortellini and F Cucinelli and G Deleonardi and F Emiliani and A Farsi and E Ferrarini and M Franchini and A Ingrassia and D Lippolis and L Losappio and Marra, {A M} and M Martini and S Masieri and Michele Mauro and M Mazzolini and L Muratore and F Murzilli and Eleonora Nucera and Pastorello, {E A} and E Pinter and Polillo, {B R} and V Pravettoni and O Quercia and Angela Rizzi and M Russello and C Sacerdoti and E Scala and G Scala and A Scarpa and J Schroeder and Uasuf, {G G} and D Villalta and B Yang and G Mistrello and S Amato and J Lidholm",

year = "2020",

doi = "10.18176/jiaci.0542",

language = "English",

volume = "32",

pages = "N/A--N/A",

journal = "JOURNAL OF INVESTIGATIONAL ALLERGOLOGY & CLINICAL IMMUNOLOGY",

issn = "1018-9068",

publisher = "Prous Science Publishers:Provenza 388, 08025 Barcelona Spain:011 34 3 4592220, EMAIL: [email protected], INTERNET: http://www.prous.com, Fax: 011 34 3 4581535",

}

Asero, R, Abbadessa, S, Aruanno, A, Barilaro, G, Barzaghi, C, Bignardi, D, Bilò, MB, Borro, M, Bresciani, MT, Busa, M, Buzzulini, F, Cavaliere, C, Cecchi, L, Ciccarelli, A, Cortellini, G, Cucinelli, F, Deleonardi, G, Emiliani, F, Farsi, A, Ferrarini, E, Franchini, M, Ingrassia, A, Lippolis, D, Losappio, L, Marra, AM, Martini, M, Masieri, S, Mauro, M, Mazzolini, M, Muratore, L, Murzilli, F, Nucera, E, Pastorello, EA, Pinter, E, Polillo, BR, Pravettoni, V, Quercia, O, Rizzi, A, Russello, M, Sacerdoti, C, Scala, E, Scala, G, Scarpa, A, Schroeder, J, Uasuf, GG, Villalta, D, Yang, B, Mistrello, G, Amato, S & Lidholm, J 2020, 'Detection of Gibberellin-Regulated Protein (Peamaclein) Sensitization among Italian Cypress Pollen-Sensitized Patients', JOURNAL OF INVESTIGATIONAL ALLERGOLOGY & CLINICAL IMMUNOLOGY, vol. 32, pp. N/A-N/A. https://doi.org/10.18176/jiaci.0542

TY - JOUR

T1 - Detection of Gibberellin-Regulated Protein (Peamaclein) Sensitization among Italian Cypress Pollen-Sensitized Patients

AU - Asero, R

AU - Abbadessa, S

AU - Aruanno, A

AU - Barilaro, G

AU - Barzaghi, C

AU - Bignardi, D

AU - Bilò, M B

AU - Borro, M

AU - Bresciani, Marco Torkel

AU - Busa, M

AU - Buzzulini, F

AU - Cavaliere, C

AU - Cecchi, L

AU - Ciccarelli, A

AU - Cortellini, G

AU - Cucinelli, F

AU - Deleonardi, G

AU - Emiliani, F

AU - Farsi, A

AU - Ferrarini, E

AU - Franchini, M

AU - Ingrassia, A

AU - Lippolis, D

AU - Losappio, L

AU - Marra, A M

AU - Martini, M

AU - Masieri, S

AU - Mauro, Michele

AU - Mazzolini, M

AU - Muratore, L

AU - Murzilli, F

AU - Nucera, Eleonora

AU - Pastorello, E A

AU - Pinter, E

AU - Polillo, B R

AU - Pravettoni, V

AU - Quercia, O

AU - Rizzi, Angela

AU - Russello, M

AU - Sacerdoti, C

AU - Scala, E

AU - Scala, G

AU - Scarpa, A

AU - Schroeder, J

AU - Uasuf, G G

AU - Villalta, D

AU - Yang, B

AU - Mistrello, G

AU - Amato, S

AU - Lidholm, J

PY - 2020

Y1 - 2020

N2 - Background: Peach gibberellin-regulated protein (peamaclein) has recently emerged as a relevant food allergen in cypress pollen-hypersensitive patients. Objective: We looked for mono-sensitization to peamaclein among Italian cypress-pollen allergic patients. Material and methods: 835 cypress pollen hypersensitive patients from 28 Italian allergy centers under went thorough interview for food-allergic reactions, and SPT with a commercial peach extracts containing peamaclein. In peach reactors, IgE to rPru p 3 was measured, and those scoring negative were enrolled as potentially mono-sensitized to peamaclein. IgE reactivity to rPru p 7 was evaluated by immunoblot and by an experimental ImmunoCAP with rPru p 7. Results: Peach SPT scored positive in 163 (19.5%) patients but 127 (77,9%) were excluded because Pru p 3 reactors. Twenty-four (14,7%, corresponding to 2.8% of the entire study population) were considered as potentially mono-sensitized to peamaclein. Their distribution did not show any geographic preference. Seventeen/24 (70,8%) had a history of food allergy, in most cases (n=15) to peach. Other offending foods included other Rosaceae, citrus fruits, fig, melon, tree nuts, and kiwi. On peach immunoblot, only 3/18 putative peamaclein allergic subjects reacted to a band at about 7kDa; 4 other patients reacted at about 50-60 kDa. Ten/18 (56%) scored positive for Pru p 7 on ImmunoCAP. Conclusion: Peamaclein allergy and sensitization prevalence seem rare in Italy. Most patients react to peach, albeit other Rosaceae fruits and several citrus fruits may also act as offending foods. Peach and cypress pollen probably share also cross-reacting allergens other than peamaclein.

AB - Background: Peach gibberellin-regulated protein (peamaclein) has recently emerged as a relevant food allergen in cypress pollen-hypersensitive patients. Objective: We looked for mono-sensitization to peamaclein among Italian cypress-pollen allergic patients. Material and methods: 835 cypress pollen hypersensitive patients from 28 Italian allergy centers under went thorough interview for food-allergic reactions, and SPT with a commercial peach extracts containing peamaclein. In peach reactors, IgE to rPru p 3 was measured, and those scoring negative were enrolled as potentially mono-sensitized to peamaclein. IgE reactivity to rPru p 7 was evaluated by immunoblot and by an experimental ImmunoCAP with rPru p 7. Results: Peach SPT scored positive in 163 (19.5%) patients but 127 (77,9%) were excluded because Pru p 3 reactors. Twenty-four (14,7%, corresponding to 2.8% of the entire study population) were considered as potentially mono-sensitized to peamaclein. Their distribution did not show any geographic preference. Seventeen/24 (70,8%) had a history of food allergy, in most cases (n=15) to peach. Other offending foods included other Rosaceae, citrus fruits, fig, melon, tree nuts, and kiwi. On peach immunoblot, only 3/18 putative peamaclein allergic subjects reacted to a band at about 7kDa; 4 other patients reacted at about 50-60 kDa. Ten/18 (56%) scored positive for Pru p 7 on ImmunoCAP. Conclusion: Peamaclein allergy and sensitization prevalence seem rare in Italy. Most patients react to peach, albeit other Rosaceae fruits and several citrus fruits may also act as offending foods. Peach and cypress pollen probably share also cross-reacting allergens other than peamaclein.

KW - Cypress pollen allergy

KW - Food allergy

KW - Peach

KW - Peamaclein

KW - Pollen food syndrome

KW - Cypress pollen allergy

KW - Food allergy

KW - Peach

KW - Peamaclein

KW - Pollen food syndrome

UR - http://hdl.handle.net/10807/161320

U2 - 10.18176/jiaci.0542

DO - 10.18176/jiaci.0542

M3 - Article

SN - 1018-9068

VL - 32

SP - N/A-N/A

JO - JOURNAL OF INVESTIGATIONAL ALLERGOLOGY & CLINICAL IMMUNOLOGY

JF - JOURNAL OF INVESTIGATIONAL ALLERGOLOGY & CLINICAL IMMUNOLOGY

ER -

Detection of Gibberellin-Regulated Protein (Peamaclein) Sensitization among Italian Cypress Pollen-Sensitized Patients

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Keywords

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