Detection of cyclopropane fatty acids in human breastmilk by GC-MS

Veronica Lolli, Margherita Dall'Asta*, Augusta Caligiani, Daniele Del Rio, Miguel Angel De La Fuente, Pilar Gómez-Cortés

*Corresponding author

Research output: Contribution to journalArticle

Abstract

Cyclopropane fatty acids (CPFAs), such as dihydrosterculic acid (DHSA), are secondary fatty acids of microbial origin recently identified in foods and human plasma. Their plasmatic concentration is suggested to be affected by consumption of CPFA-rich foods, especially dairy products. However, very little is known about the occurrence of CPFAs in human tissues and their nutritional value. This preliminary screening aims to investigate the presence of CPFAs in breastmilk obtained from lactating Spanish women following a free-living diet by performing the GC–MS method previously applied for CPFA determination in dairy products. For the first time, DHSA was detected in human breast milk fat (at about 0.4 mg/ 100 mL breastmilk), supporting the importance of better understanding its occurrence in vivo that may be related to the dietary habits followed by the lactating mother. Future studies are needed to determine its biological role both in adults and infants, who would be exposed to this CPFA during the breastfeeding.
Original languageEnglish
Pages (from-to)104379-104379
Number of pages1
JournalJournal of Food Composition and Analysis
Volume107
DOIs
Publication statusPublished - 2022

Keywords

  • Breastfeeding
  • Cyclic fatty acids
  • Dihydrosterculic acid
  • GC–MS
  • Human milk
  • Lipid analysis
  • Minor fatty acids

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