Depression and disease progression in amyotrophic lateral sclerosis: A comprehensive meta-regression analysis

Francesco Pagnini, Gian Mauro Manzoni, Chris J. Gibbons

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Depression in people with amyotrophic lateral sclerosis, a fatal and progressive neurodegenerative disorder, is a serious issue with important clinical consequences. However, physical impairment may confound the diagnosis when using generic questionnaires. We conducted a comprehensive review of literature. Mean scores from depression questionnaires were meta-regressed on study-level mean time since onset of symptoms. Data from 103 studies (3190 subjects) indicate that the Beck Depression Inventory and, to a lesser degree, the Hospital Anxiety and Depression Scale are influenced by the time since symptom onset, strongly related to physical impairment. Our results suggest that widely used depression scales overestimate depression due to confounding with physical symptoms.
Original languageEnglish
Pages (from-to)1107-1128
Number of pages22
JournalJournal of Health Psychology
Volume20
DOIs
Publication statusPublished - 2015

Keywords

  • Amyotrophic Lateral Sclerosis
  • Depression
  • Disease Progression
  • Humans
  • amyotrophic lateral sclerosis
  • assessment
  • depression
  • neurology

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