Defining Global Benchmarks for Laparoscopic Liver Resections: An International Multicenter Study

Brian K.P. Goh; Ho-Seong Han; Kuo-Hsin Chen; Darren W. Chua; Chung-Yip Chan; Federica Cipriani; Davit L. Aghayan; Asmund A. Fretland; Jasper Sijberden; Mizelle D'Silva; Tiing Foong Siow; Yutaro Kato; Chetana Lim; Phan Phuoc Nghia; Paulo Herman; Marco V. Marino; Vincenzo Mazzaferro; Adrian K.H. Chiow; Iswanto Sucandy; Arpad Ivanecz; Sung Hoon Choi; Jae Hoon Lee; Mikel Gastaca; Marco Vivarelli; Felice Giuliante; Andrea Ruzzenente; Chee-Chien Yong; Mengqui Yin; Zewei Chen; Constantino Fondevila; Mikhail Efanov; Fernando Rotellar; Gi-Hong Choi; Ricardo R. Campos; Xiaoying Wang; Robert P. Sutcliffe; Johann Pratschke; Eric Lai; Charing C. Chong; Mathieu D'Hondt; Kazuteru Monden; Santiago Lopez-Ben; Fabricio F. Coelho; Thomas Peter Kingham; Rong Liu; Tran Cong Duy Long; Alessandro Ferrero; Giovanni B. Levi Sandri; Mansour Saleh; Daniel Cherqui; Olivier Scatton; Olivier Soubrane; Go Wakabayashi; Roberto I. Troisi; Tan-To Cheung; Atsushi Sugioka; Mohammad Abu Hilal; David Fuks; Bjørn Edwin; Luca Aldrighetti; Nicholas Syn; Mikel Prieto; Henri Schotte; Celine De Meyere; Felix Krenzien; Moritz Schmelzle; Kit-Fai Lee; Diana Salimgereeva; Ruslan Alikhanov; Lip-Seng Lee; Jae Young Jang; Masayuki Kojima; Jacob Ghotbi; Jaime Arthur Pirola Kruger; Victor Lopez-Lopez; Bernardo Dalla Valle; Margarida Casellas I Robert; Kohei Mishima; Roberto Montalti; Mariano Giglio; Alessandro Mazzotta; Boram Lee; Hao-Ping Wang; Franco Pascual; Prashant Kadam; Chung-Ngai Tang; Shian Yu; Francesco Ardito; Simone Vani; Ugo Giustizieri; Davide Citterio; Federico Mocchegiani; Giuseppe Maria Ettorre; Marco Colasanti; Yoelimar Guzmán

doi:10.1097/SLA.0000000000005530

Defining Global Benchmarks for Laparoscopic Liver Resections: An International Multicenter Study

Brian K.P. Goh, Ho-Seong Han, Kuo-Hsin Chen, Darren W. Chua, Chung-Yip Chan, Federica Cipriani, Davit L. Aghayan, Asmund A. Fretland, Jasper Sijberden, Mizelle D'Silva, Tiing Foong Siow, Yutaro Kato, Chetana Lim, Phan Phuoc Nghia, Paulo Herman, Marco V. Marino, Vincenzo Mazzaferro, Adrian K.H. Chiow, Iswanto Sucandy, Arpad IvaneczSung Hoon Choi, Jae Hoon Lee, Mikel Gastaca, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee-Chien Yong, Mengqui Yin, Zewei Chen, Constantino Fondevila, Mikhail Efanov, Fernando Rotellar, Gi-Hong Choi, Ricardo R. Campos, Xiaoying Wang, Robert P. Sutcliffe, Johann Pratschke, Eric Lai, Charing C. Chong, Mathieu D'Hondt, Kazuteru Monden, Santiago Lopez-Ben, Fabricio F. Coelho, Thomas Peter Kingham, Rong Liu, Tran Cong Duy Long, Alessandro Ferrero, Giovanni B. Levi Sandri, Mansour Saleh, Daniel Cherqui, Olivier Scatton, Olivier Soubrane, Go Wakabayashi, Roberto I. Troisi, Tan-To Cheung, Atsushi Sugioka, Mohammad Abu Hilal, David Fuks, Bjørn Edwin, Luca Aldrighetti, Nicholas Syn, Mikel Prieto, Henri Schotte, Celine De Meyere, Felix Krenzien, Moritz Schmelzle, Kit-Fai Lee, Diana Salimgereeva, Ruslan Alikhanov, Lip-Seng Lee, Jae Young Jang, Masayuki Kojima, Jacob Ghotbi, Jaime Arthur Pirola Kruger, Victor Lopez-Lopez, Bernardo Dalla Valle, Margarida Casellas I Robert, Kohei Mishima, Roberto Montalti, Mariano Giglio, Alessandro Mazzotta, Boram Lee, Hao-Ping Wang, Franco Pascual, Prashant Kadam, Chung-Ngai Tang, Shian Yu, Francesco Ardito, Simone Vani, Ugo Giustizieri, Davide Citterio, Federico Mocchegiani, Giuseppe Maria Ettorre, Marco Colasanti, Yoelimar Guzmán

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To establish global benchmark outcomes indicators after laparoscopic liver resections (L-LR). Background: There is limited published data to date on the best achievable outcomes after L-LR. Methods: This is a post hoc analysis of a multicenter database of 11,983 patients undergoing L-LR in 45 international centers in 4 continents between 2015 and 2020. Three specific procedures: left lateral sectionectomy (LLS), left hepatectomy (LH), and right hepatectomy (RH) were selected to represent the 3 difficulty levels of L-LR. Fifteen outcome indicators were selected to establish benchmark cutoffs. Results: There were 3519 L-LR (LLS, LH, RH) of which 1258 L-LR (40.6%) cases performed in 34 benchmark expert centers qualified as low-risk benchmark cases. These included 659 LLS (52.4%), 306 LH (24.3%), and 293 RH (23.3%). The benchmark outcomes established for operation time, open conversion rate, blood loss ≥500 mL, blood transfusion rate, postoperative morbidity, major morbidity, and 90-day mortality after LLS, LH, and RH were 209.5, 302, and 426 minutes; 2.1%, 13.4%, and 13.0%; 3.2%, 20%, and 47.1%; 0%, 7.1%, and 10.5%; 11.1%, 20%, and 50%; 0%, 7.1%, and 20%; and 0%, 0%, and 0%, respectively. Conclusions: This study established the first global benchmark outcomes for L-LR in a large-scale international patient cohort. It provides an up-to-date reference regarding the "best achievable" results for L-LR for which centers adopting L-LR can use as a comparison to enable an objective assessment of performance gaps and learning curves.

Original language	English
Pages (from-to)	839-848
Number of pages	10
Journal	Annals of Surgery
Volume	277
DOIs	https://doi.org/10.1097/SLA.0000000000005530
Publication status	Published - 2023

Keywords

benchmark
global
hepatectomy
laparoscopic liver resection
minimally invasive
quality assessment

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10.1097/SLA.0000000000005530

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Goh, B. K. P., Han, H.-S., Chen, K.-H., Chua, D. W., Chan, C.-Y., Cipriani, F., Aghayan, D. L., Fretland, A. A., Sijberden, J., D'Silva, M., Siow, T. F., Kato, Y., Lim, C., Nghia, P. P., Herman, P., Marino, M. V., Mazzaferro, V., Chiow, A. K. H., Sucandy, I., ... Guzmán, Y. (2023). Defining Global Benchmarks for Laparoscopic Liver Resections: An International Multicenter Study. Annals of Surgery, 277, 839-848. https://doi.org/10.1097/SLA.0000000000005530

@article{acee68818345445b803fde64028da1f8,

title = "Defining Global Benchmarks for Laparoscopic Liver Resections: An International Multicenter Study",

abstract = "Objective: To establish global benchmark outcomes indicators after laparoscopic liver resections (L-LR). Background: There is limited published data to date on the best achievable outcomes after L-LR. Methods: This is a post hoc analysis of a multicenter database of 11,983 patients undergoing L-LR in 45 international centers in 4 continents between 2015 and 2020. Three specific procedures: left lateral sectionectomy (LLS), left hepatectomy (LH), and right hepatectomy (RH) were selected to represent the 3 difficulty levels of L-LR. Fifteen outcome indicators were selected to establish benchmark cutoffs. Results: There were 3519 L-LR (LLS, LH, RH) of which 1258 L-LR (40.6%) cases performed in 34 benchmark expert centers qualified as low-risk benchmark cases. These included 659 LLS (52.4%), 306 LH (24.3%), and 293 RH (23.3%). The benchmark outcomes established for operation time, open conversion rate, blood loss ≥500 mL, blood transfusion rate, postoperative morbidity, major morbidity, and 90-day mortality after LLS, LH, and RH were 209.5, 302, and 426 minutes; 2.1%, 13.4%, and 13.0%; 3.2%, 20%, and 47.1%; 0%, 7.1%, and 10.5%; 11.1%, 20%, and 50%; 0%, 7.1%, and 20%; and 0%, 0%, and 0%, respectively. Conclusions: This study established the first global benchmark outcomes for L-LR in a large-scale international patient cohort. It provides an up-to-date reference regarding the {"}best achievable{"} results for L-LR for which centers adopting L-LR can use as a comparison to enable an objective assessment of performance gaps and learning curves.",

keywords = "benchmark, global, hepatectomy, laparoscopic liver resection, minimally invasive, quality assessment, benchmark, global, hepatectomy, laparoscopic liver resection, minimally invasive, quality assessment",

author = "Goh, {Brian K.P.} and Ho-Seong Han and Kuo-Hsin Chen and Chua, {Darren W.} and Chung-Yip Chan and Federica Cipriani and Aghayan, {Davit L.} and Fretland, {Asmund A.} and Jasper Sijberden and Mizelle D'Silva and Siow, {Tiing Foong} and Yutaro Kato and Chetana Lim and Nghia, {Phan Phuoc} and Paulo Herman and Marino, {Marco V.} and Vincenzo Mazzaferro and Chiow, {Adrian K.H.} and Iswanto Sucandy and Arpad Ivanecz and Choi, {Sung Hoon} and Lee, {Jae Hoon} and Mikel Gastaca and Marco Vivarelli and Felice Giuliante and Andrea Ruzzenente and Chee-Chien Yong and Mengqui Yin and Zewei Chen and Constantino Fondevila and Mikhail Efanov and Fernando Rotellar and Gi-Hong Choi and Campos, {Ricardo R.} and Xiaoying Wang and Sutcliffe, {Robert P.} and Johann Pratschke and Eric Lai and Chong, {Charing C.} and Mathieu D'Hondt and Kazuteru Monden and Santiago Lopez-Ben and Coelho, {Fabricio F.} and Kingham, {Thomas Peter} and Rong Liu and Long, {Tran Cong Duy} and Alessandro Ferrero and Sandri, {Giovanni B. Levi} and Mansour Saleh and Daniel Cherqui and Olivier Scatton and Olivier Soubrane and Go Wakabayashi and Troisi, {Roberto I.} and Tan-To Cheung and Atsushi Sugioka and Hilal, {Mohammad Abu} and David Fuks and Bj{\o}rn Edwin and Luca Aldrighetti and Nicholas Syn and Mikel Prieto and Henri Schotte and {De Meyere}, Celine and Felix Krenzien and Moritz Schmelzle and Kit-Fai Lee and Diana Salimgereeva and Ruslan Alikhanov and Lip-Seng Lee and Jang, {Jae Young} and Masayuki Kojima and Jacob Ghotbi and Kruger, {Jaime Arthur Pirola} and Victor Lopez-Lopez and Valle, {Bernardo Dalla} and {Casellas I Robert}, Margarida and Kohei Mishima and Roberto Montalti and Mariano Giglio and Alessandro Mazzotta and Boram Lee and Hao-Ping Wang and Franco Pascual and Prashant Kadam and Chung-Ngai Tang and Shian Yu and Francesco Ardito and Simone Vani and Ugo Giustizieri and Davide Citterio and Federico Mocchegiani and Ettorre, {Giuseppe Maria} and Marco Colasanti and Yoelimar Guzm{\'a}n",

year = "2023",

doi = "10.1097/SLA.0000000000005530",

language = "English",

volume = "277",

pages = "839--848",

journal = "Annals of Surgery",

issn = "0003-4932",

publisher = "Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: [email protected], INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320",

}

Goh, BKP, Han, H-S, Chen, K-H, Chua, DW, Chan, C-Y, Cipriani, F, Aghayan, DL, Fretland, AA, Sijberden, J, D'Silva, M, Siow, TF, Kato, Y, Lim, C, Nghia, PP, Herman, P, Marino, MV, Mazzaferro, V, Chiow, AKH, Sucandy, I, Ivanecz, A, Choi, SH, Lee, JH, Gastaca, M, Vivarelli, M, Giuliante, F, Ruzzenente, A, Yong, C-C, Yin, M, Chen, Z, Fondevila, C, Efanov, M, Rotellar, F, Choi, G-H, Campos, RR, Wang, X, Sutcliffe, RP, Pratschke, J, Lai, E, Chong, CC, D'Hondt, M, Monden, K, Lopez-Ben, S, Coelho, FF, Kingham, TP, Liu, R, Long, TCD, Ferrero, A, Sandri, GBL, Saleh, M, Cherqui, D, Scatton, O, Soubrane, O, Wakabayashi, G, Troisi, RI, Cheung, T-T, Sugioka, A, Hilal, MA, Fuks, D, Edwin, B, Aldrighetti, L, Syn, N, Prieto, M, Schotte, H, De Meyere, C, Krenzien, F, Schmelzle, M, Lee, K-F, Salimgereeva, D, Alikhanov, R, Lee, L-S, Jang, JY, Kojima, M, Ghotbi, J, Kruger, JAP, Lopez-Lopez, V, Valle, BD, Casellas I Robert, M, Mishima, K, Montalti, R, Giglio, M, Mazzotta, A, Lee, B, Wang, H-P, Pascual, F, Kadam, P, Tang, C-N, Yu, S, Ardito, F, Vani, S, Giustizieri, U, Citterio, D, Mocchegiani, F, Ettorre, GM, Colasanti, M & Guzmán, Y 2023, 'Defining Global Benchmarks for Laparoscopic Liver Resections: An International Multicenter Study', Annals of Surgery, vol. 277, pp. 839-848. https://doi.org/10.1097/SLA.0000000000005530

TY - JOUR

T1 - Defining Global Benchmarks for Laparoscopic Liver Resections: An International Multicenter Study

AU - Goh, Brian K.P.

AU - Han, Ho-Seong

AU - Chen, Kuo-Hsin

AU - Chua, Darren W.

AU - Chan, Chung-Yip

AU - Cipriani, Federica

AU - Aghayan, Davit L.

AU - Fretland, Asmund A.

AU - Sijberden, Jasper

AU - D'Silva, Mizelle

AU - Siow, Tiing Foong

AU - Kato, Yutaro

AU - Lim, Chetana

AU - Nghia, Phan Phuoc

AU - Herman, Paulo

AU - Marino, Marco V.

AU - Mazzaferro, Vincenzo

AU - Chiow, Adrian K.H.

AU - Sucandy, Iswanto

AU - Ivanecz, Arpad

AU - Choi, Sung Hoon

AU - Lee, Jae Hoon

AU - Gastaca, Mikel

AU - Vivarelli, Marco

AU - Giuliante, Felice

AU - Ruzzenente, Andrea

AU - Yong, Chee-Chien

AU - Yin, Mengqui

AU - Chen, Zewei

AU - Fondevila, Constantino

AU - Efanov, Mikhail

AU - Rotellar, Fernando

AU - Choi, Gi-Hong

AU - Campos, Ricardo R.

AU - Wang, Xiaoying

AU - Sutcliffe, Robert P.

AU - Pratschke, Johann

AU - Lai, Eric

AU - Chong, Charing C.

AU - D'Hondt, Mathieu

AU - Monden, Kazuteru

AU - Lopez-Ben, Santiago

AU - Coelho, Fabricio F.

AU - Kingham, Thomas Peter

AU - Liu, Rong

AU - Long, Tran Cong Duy

AU - Ferrero, Alessandro

AU - Sandri, Giovanni B. Levi

AU - Saleh, Mansour

AU - Cherqui, Daniel

AU - Scatton, Olivier

AU - Soubrane, Olivier

AU - Wakabayashi, Go

AU - Troisi, Roberto I.

AU - Cheung, Tan-To

AU - Sugioka, Atsushi

AU - Hilal, Mohammad Abu

AU - Fuks, David

AU - Edwin, Bjørn

AU - Aldrighetti, Luca

AU - Syn, Nicholas

AU - Prieto, Mikel

AU - Schotte, Henri

AU - De Meyere, Celine

AU - Krenzien, Felix

AU - Schmelzle, Moritz

AU - Lee, Kit-Fai

AU - Salimgereeva, Diana

AU - Alikhanov, Ruslan

AU - Lee, Lip-Seng

AU - Jang, Jae Young

AU - Kojima, Masayuki

AU - Ghotbi, Jacob

AU - Kruger, Jaime Arthur Pirola

AU - Lopez-Lopez, Victor

AU - Valle, Bernardo Dalla

AU - Casellas I Robert, Margarida

AU - Mishima, Kohei

AU - Montalti, Roberto

AU - Giglio, Mariano

AU - Mazzotta, Alessandro

AU - Lee, Boram

AU - Wang, Hao-Ping

AU - Pascual, Franco

AU - Kadam, Prashant

AU - Tang, Chung-Ngai

AU - Yu, Shian

AU - Ardito, Francesco

AU - Vani, Simone

AU - Giustizieri, Ugo

AU - Citterio, Davide

AU - Mocchegiani, Federico

AU - Ettorre, Giuseppe Maria

AU - Colasanti, Marco

AU - Guzmán, Yoelimar

PY - 2023

Y1 - 2023

N2 - Objective: To establish global benchmark outcomes indicators after laparoscopic liver resections (L-LR). Background: There is limited published data to date on the best achievable outcomes after L-LR. Methods: This is a post hoc analysis of a multicenter database of 11,983 patients undergoing L-LR in 45 international centers in 4 continents between 2015 and 2020. Three specific procedures: left lateral sectionectomy (LLS), left hepatectomy (LH), and right hepatectomy (RH) were selected to represent the 3 difficulty levels of L-LR. Fifteen outcome indicators were selected to establish benchmark cutoffs. Results: There were 3519 L-LR (LLS, LH, RH) of which 1258 L-LR (40.6%) cases performed in 34 benchmark expert centers qualified as low-risk benchmark cases. These included 659 LLS (52.4%), 306 LH (24.3%), and 293 RH (23.3%). The benchmark outcomes established for operation time, open conversion rate, blood loss ≥500 mL, blood transfusion rate, postoperative morbidity, major morbidity, and 90-day mortality after LLS, LH, and RH were 209.5, 302, and 426 minutes; 2.1%, 13.4%, and 13.0%; 3.2%, 20%, and 47.1%; 0%, 7.1%, and 10.5%; 11.1%, 20%, and 50%; 0%, 7.1%, and 20%; and 0%, 0%, and 0%, respectively. Conclusions: This study established the first global benchmark outcomes for L-LR in a large-scale international patient cohort. It provides an up-to-date reference regarding the "best achievable" results for L-LR for which centers adopting L-LR can use as a comparison to enable an objective assessment of performance gaps and learning curves.

AB - Objective: To establish global benchmark outcomes indicators after laparoscopic liver resections (L-LR). Background: There is limited published data to date on the best achievable outcomes after L-LR. Methods: This is a post hoc analysis of a multicenter database of 11,983 patients undergoing L-LR in 45 international centers in 4 continents between 2015 and 2020. Three specific procedures: left lateral sectionectomy (LLS), left hepatectomy (LH), and right hepatectomy (RH) were selected to represent the 3 difficulty levels of L-LR. Fifteen outcome indicators were selected to establish benchmark cutoffs. Results: There were 3519 L-LR (LLS, LH, RH) of which 1258 L-LR (40.6%) cases performed in 34 benchmark expert centers qualified as low-risk benchmark cases. These included 659 LLS (52.4%), 306 LH (24.3%), and 293 RH (23.3%). The benchmark outcomes established for operation time, open conversion rate, blood loss ≥500 mL, blood transfusion rate, postoperative morbidity, major morbidity, and 90-day mortality after LLS, LH, and RH were 209.5, 302, and 426 minutes; 2.1%, 13.4%, and 13.0%; 3.2%, 20%, and 47.1%; 0%, 7.1%, and 10.5%; 11.1%, 20%, and 50%; 0%, 7.1%, and 20%; and 0%, 0%, and 0%, respectively. Conclusions: This study established the first global benchmark outcomes for L-LR in a large-scale international patient cohort. It provides an up-to-date reference regarding the "best achievable" results for L-LR for which centers adopting L-LR can use as a comparison to enable an objective assessment of performance gaps and learning curves.

KW - benchmark

KW - global

KW - hepatectomy

KW - laparoscopic liver resection

KW - minimally invasive

KW - quality assessment

KW - benchmark

KW - global

KW - hepatectomy

KW - laparoscopic liver resection

KW - minimally invasive

KW - quality assessment

UR - http://hdl.handle.net/10807/231552

U2 - 10.1097/SLA.0000000000005530

DO - 10.1097/SLA.0000000000005530

M3 - Article

SN - 0003-4932

VL - 277

SP - 839

EP - 848

JO - Annals of Surgery

JF - Annals of Surgery

ER -

Defining Global Benchmarks for Laparoscopic Liver Resections: An International Multicenter Study

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