Decreased expression of heparin-binding epidermal growth factor-like growth factor as a newly identified pathogenic mechanism of antiphospholipid-mediated defective placentation

Maurizio Sanguinetti, Nicoletta Di Simone, Riccardo Marana, Roberta Castellani, Fiorella Di Nicuolo, Alessandro Caruso, E. Raschi, M. O. Borghi, P. P. Chen, P. L. Meroni

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) plays a role in blastocyst implantation and is down-regulated in preeclampsia and in hypertensive pregnancy disorders associated with defective extravillous trophoblast invasion. Defective placentation and severe preeclampsia are also features of the antiphospholipid syndrome (APS). The purpose of this study was to investigate whether abnormal HB-EGF expression plays a pathogenic role in antiphospholipid antibody (aPL)-mediated defective placentation.
Original languageEnglish
Pages (from-to)1504-1512
Number of pages9
JournalArthritis and Rheumatism
DOIs
Publication statusPublished - 2010

Keywords

  • Adult
  • Antibodies, Antiphospholipid
  • Antibodies, Monoclonal
  • Anticoagulants
  • Antiphospholipid Syndrome
  • Blotting, Western
  • Cells, Cultured
  • Down-Regulation
  • Female
  • Gene Expression
  • Heparin, Low-Molecular-Weight
  • Humans
  • Intercellular Signaling Peptides and Proteins
  • Matrix Metalloproteinase 2
  • Matrix Metalloproteinase 9
  • Pilot Projects
  • Placenta Diseases
  • Pregnancy
  • RNA, Messenger
  • Trophoblasts
  • beta 2-Glycoprotein I

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