Declining HCV seroprevalence in pregnant women with HIV

M Floridia, Enrica Tamburrini, G Anzidei, C Tibaldi, Ml Muggiasca, G Guaraldi, M Fiscon, A Vimercati, P Martinelli, A Donisi, S Dalzero, M. Ravizza

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5 Citations (Scopus)


We assessed recent trends in hepatitis C virus (HCV) prevalence in pregnant women with HIV using data from a large national study. Based on 1240 pregnancies, we observed a 3.4-fold decline in HCV seroprevalence in pregnant women with HIV between 2001 (29.3%) and 2008 (8.6%). This decline was the net result of two components: a progressively declining HCV seroprevalence in non-African women (from 35.7% in 2001 to 16.7% in 2008), sustained by a parallel reduction in history of injecting drug use (IDU) in this population, and a significantly growing presence (from 21.2% in 2001 to 48.6% in 2008) of women of African origin, at very low risk of being HCV-infected [average HCV prevalence 1%, adjusted odds ratio (aOR) for HCV 0.09, 95% CI 0.03-0.29]. Previous IDU was the stronger determinant of HCV co-infection in pregnant women with HIV (aOR 30.9, 95% CI 18.8-51.1). The observed trend is expected to translate into a reduced number of cases of vertical HCV transmission.
Original languageEnglish
Pages (from-to)1317-1321
Number of pages5
JournalEpidemiology and Infection
Publication statusPublished - 2009


  • Chi-Square Distribution
  • Female
  • HIV Infections
  • Hepatitis C
  • Humans
  • Italy
  • Logistic Models
  • Pregnancy
  • Risk Factors
  • Seroepidemiologic Studies


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