De novo expression of calretinin in trimethyltin-induced degeneration of developing rat hippocampus

Valentina Corvino; Maria Concetta Geloso; Elena De Santis; Fabrizio Michetti; Rita Businaro; Lorenzo Fumagalli

De novo expression of calretinin in trimethyltin-induced degeneration of developing rat hippocampus

Valentina Corvino, Maria Concetta Geloso, Elena De Santis, Fabrizio Michetti, Rita Businaro, Lorenzo Fumagalli

Research output: Contribution to journal › Article › peer-review

Abstract

In the model of trimethyltin (TMT)-induced neurodegeneration in developing rat hippocampus, calretinin (CR)-immunoreactive neurons are selectively spared and even more numerous than in controls. We investigated the possibility of an additional synthesis of CR using RT-PCR. The amount of CR mRNA increased significantly after TMT treatment. CR mRNA production after TMT treatment could hypothetically be regarded as a compensatory phenomenon in developing rats.

Original language	English
Pages (from-to)	141-144
Number of pages	4
Journal	Molecular Brain Research
Publication status	Published - 2002

Keywords

Calretinin
Development
Neurodegeneration
Trimethyltin

Cite this

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title = "De novo expression of calretinin in trimethyltin-induced degeneration of developing rat hippocampus",

abstract = "In the model of trimethyltin (TMT)-induced neurodegeneration in developing rat hippocampus, calretinin (CR)-immunoreactive neurons are selectively spared and even more numerous than in controls. We investigated the possibility of an additional synthesis of CR using RT-PCR. The amount of CR mRNA increased significantly after TMT treatment. CR mRNA production after TMT treatment could hypothetically be regarded as a compensatory phenomenon in developing rats.",

keywords = "Calretinin, Development, Neurodegeneration, Trimethyltin, Calretinin, Development, Neurodegeneration, Trimethyltin",

author = "Valentina Corvino and Geloso, {Maria Concetta} and {De Santis}, Elena and Fabrizio Michetti and Rita Businaro and Lorenzo Fumagalli",

year = "2002",

language = "English",

pages = "141--144",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598",

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TY - JOUR

T1 - De novo expression of calretinin in trimethyltin-induced degeneration of developing rat hippocampus

AU - Corvino, Valentina

AU - Geloso, Maria Concetta

AU - De Santis, Elena

AU - Michetti, Fabrizio

AU - Businaro, Rita

AU - Fumagalli, Lorenzo

PY - 2002

Y1 - 2002

N2 - In the model of trimethyltin (TMT)-induced neurodegeneration in developing rat hippocampus, calretinin (CR)-immunoreactive neurons are selectively spared and even more numerous than in controls. We investigated the possibility of an additional synthesis of CR using RT-PCR. The amount of CR mRNA increased significantly after TMT treatment. CR mRNA production after TMT treatment could hypothetically be regarded as a compensatory phenomenon in developing rats.

AB - In the model of trimethyltin (TMT)-induced neurodegeneration in developing rat hippocampus, calretinin (CR)-immunoreactive neurons are selectively spared and even more numerous than in controls. We investigated the possibility of an additional synthesis of CR using RT-PCR. The amount of CR mRNA increased significantly after TMT treatment. CR mRNA production after TMT treatment could hypothetically be regarded as a compensatory phenomenon in developing rats.

KW - Calretinin

KW - Development

KW - Neurodegeneration

KW - Trimethyltin

KW - Calretinin

KW - Development

KW - Neurodegeneration

KW - Trimethyltin

UR - http://hdl.handle.net/10807/8200

M3 - Article

SP - 141

EP - 144

JO - Brain Research

JF - Brain Research

SN - 0006-8993

ER -

De novo expression of calretinin in trimethyltin-induced degeneration of developing rat hippocampus

Abstract

Keywords

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