De novo expression of calretinin in trimethyltin-induced degeneration of developing rat hippocampus

Valentina Corvino, Maria Concetta Geloso, Elena De Santis, Fabrizio Michetti, Rita Businaro, Lorenzo Fumagalli

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

In the model of trimethyltin (TMT)-induced neurodegeneration in developing rat hippocampus, calretinin (CR)-immunoreactive neurons are selectively spared and even more numerous than in controls. We investigated the possibility of an additional synthesis of CR using RT-PCR. The amount of CR mRNA increased significantly after TMT treatment. CR mRNA production after TMT treatment could hypothetically be regarded as a compensatory phenomenon in developing rats.
Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalMolecular Brain Research
Publication statusPublished - 2002

Keywords

  • Calretinin
  • Development
  • Neurodegeneration
  • Trimethyltin

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