DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma

Maria Teresa Voso; Daniela Gumiero; Francesco D'Alo'; Francesco Guidi; Giovanna Rosaria Mansueto; Annalaura Di Febo; Giuseppina Massini; Maurizio Martini; Luigi Maria Larocca; Stefan Hohaus; Giuseppe Leone

DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma

Maria Teresa Voso, Daniela Gumiero, Francesco D'Alo', Francesco Guidi, Giovanna Rosaria Mansueto, Annalaura Di Febo, Giuseppina Massini, Maurizio Martini, Luigi Maria Larocca, Stefan Hohaus, Giuseppe Leone

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Abstract

We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p<0.001).

Original language	English
Pages (from-to)	1252-1256
Number of pages	5
Journal	Haematologica
Volume	91
Publication status	Published - 2006

Keywords

Adult
Aged
Apoptosis Regulatory Proteins
Bone Marrow
Calcium-Calmodulin-Dependent Protein Kinases
DNA Methylation
Female
Humans
Lymphoma, Follicular
Male
Middle Aged
Prognosis
Treatment Outcome
Tumor Markers, Biological

Cite this

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title = "DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma",

abstract = "We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p<0.001).",

keywords = "Adult, Aged, Apoptosis Regulatory Proteins, Bone Marrow, Calcium-Calmodulin-Dependent Protein Kinases, DNA Methylation, Female, Humans, Lymphoma, Follicular, Male, Middle Aged, Prognosis, Treatment Outcome, Tumor Markers, Biological, Adult, Aged, Apoptosis Regulatory Proteins, Bone Marrow, Calcium-Calmodulin-Dependent Protein Kinases, DNA Methylation, Female, Humans, Lymphoma, Follicular, Male, Middle Aged, Prognosis, Treatment Outcome, Tumor Markers, Biological",

author = "Voso, {Maria Teresa} and Daniela Gumiero and Francesco D'Alo' and Francesco Guidi and Mansueto, {Giovanna Rosaria} and {Di Febo}, Annalaura and Giuseppina Massini and Maurizio Martini and Larocca, {Luigi Maria} and Stefan Hohaus and Giuseppe Leone",

year = "2006",

language = "English",

volume = "91",

pages = "1252--1256",

journal = "Haematologica",

issn = "1592-8721",

publisher = "Ferrata Storti Foundation",

}

TY - JOUR

T1 - DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma

AU - Voso, Maria Teresa

AU - Gumiero, Daniela

AU - D'Alo', Francesco

AU - Guidi, Francesco

AU - Mansueto, Giovanna Rosaria

AU - Di Febo, Annalaura

AU - Massini, Giuseppina

AU - Martini, Maurizio

AU - Larocca, Luigi Maria

AU - Hohaus, Stefan

AU - Leone, Giuseppe

PY - 2006

Y1 - 2006

N2 - We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p<0.001).

AB - We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p<0.001).

KW - Adult

KW - Aged

KW - Apoptosis Regulatory Proteins

KW - Bone Marrow

KW - Calcium-Calmodulin-Dependent Protein Kinases

KW - DNA Methylation

KW - Female

KW - Humans

KW - Lymphoma, Follicular

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Treatment Outcome

KW - Tumor Markers, Biological

KW - Adult

KW - Aged

KW - Apoptosis Regulatory Proteins

KW - Bone Marrow

KW - Calcium-Calmodulin-Dependent Protein Kinases

KW - DNA Methylation

KW - Female

KW - Humans

KW - Lymphoma, Follicular

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Treatment Outcome

KW - Tumor Markers, Biological

UR - http://hdl.handle.net/10807/26434

M3 - Article

SN - 1592-8721

VL - 91

SP - 1252

EP - 1256

JO - Haematologica

JF - Haematologica

ER -

DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma

Abstract

Keywords

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