Abstract
We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p<0.001).
Original language | English |
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Pages (from-to) | 1252-1256 |
Number of pages | 5 |
Journal | Haematologica |
Volume | 91 |
Publication status | Published - 2006 |
Keywords
- Adult
- Aged
- Apoptosis Regulatory Proteins
- Bone Marrow
- Calcium-Calmodulin-Dependent Protein Kinases
- DNA Methylation
- Female
- Humans
- Lymphoma, Follicular
- Male
- Middle Aged
- Prognosis
- Treatment Outcome
- Tumor Markers, Biological