DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma

Francesco D'Alo', Maurizio Martini, Luigi Maria Larocca, Stefan Hohaus, Maria Teresa Voso, Daniela Gumiero, Francesco Guidi, Giovanna Rosaria Mansueto, Annalaura Di Febo, Giuseppina Massini, Giuseppe Leone

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Abstract

We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p<0.001).
Original languageEnglish
Pages (from-to)1252-1256
Number of pages5
JournalHaematologica
Volume91
Publication statusPublished - 2006

Keywords

  • Adult
  • Aged
  • Apoptosis Regulatory Proteins
  • Bone Marrow
  • Calcium-Calmodulin-Dependent Protein Kinases
  • DNA Methylation
  • Female
  • Humans
  • Lymphoma, Follicular
  • Male
  • Middle Aged
  • Prognosis
  • Treatment Outcome
  • Tumor Markers, Biological

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