Cytokine profile of autologous platelet-derived eye drops in patients with ocular chronic graft-versus-host disease

Caterina Giovanna Valentini; Eugenia Rosa Nuzzolo; N. Orlando; Elisabetta Metafuni; M. Bianchi; Patrizia Chiusolo; Gina Zini Tanzi; Luciana Teofili

doi:10.1111/vox.12325

Cytokine profile of autologous platelet-derived eye drops in patients with ocular chronic graft-versus-host disease

Caterina Giovanna Valentini, Eugenia Rosa Nuzzolo, N. Orlando, Elisabetta Metafuni, M. Bianchi, Patrizia Chiusolo, Gina Zini Tanzi, Luciana Teofili^*

^*Corresponding author

Research output: Contribution to journal › Article

9 Citations (Scopus)

Abstract

Ocular chronic GVHD is efficaciously treated with autologous platelet-derived eye drops. We investigated the cytokine content of eye drops produced using a non-gelified lysate obtained from autologous platelet-rich plasma in six patients with ocular GVHD. In both the responding (n = 4) and the resistant (n = 2) patients, the eye drops were significantly enriched with various growth factors, in amounts proportional with the platelet counts. In contrast, chemokine ligand and interleukin levels were similar to those of plasma. The non-responding patients showed the highest levels of chemokine (C-X-C motif) ligand (CXCL)10. These findings provide possible explanations for beneficial or detrimental effects of eye drops.

Original language	English
Pages (from-to)	189-192
Number of pages	4
Journal	Vox Sanguinis
Volume	110
DOIs	https://doi.org/10.1111/vox.12325
Publication status	Published - 2016

Keywords

Adult
Autologous platelet lysates
Blood Platelets
Chemokines
Cytokines
Dry eye syndrome
Female
GVHD
Graft vs Host Disease
Growth factors
Hematology
Humans
Male
Middle Aged
Ophthalmic Solutions

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10.1111/vox.12325

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title = "Cytokine profile of autologous platelet-derived eye drops in patients with ocular chronic graft-versus-host disease",

abstract = "Ocular chronic GVHD is efficaciously treated with autologous platelet-derived eye drops. We investigated the cytokine content of eye drops produced using a non-gelified lysate obtained from autologous platelet-rich plasma in six patients with ocular GVHD. In both the responding (n = 4) and the resistant (n = 2) patients, the eye drops were significantly enriched with various growth factors, in amounts proportional with the platelet counts. In contrast, chemokine ligand and interleukin levels were similar to those of plasma. The non-responding patients showed the highest levels of chemokine (C-X-C motif) ligand (CXCL)10. These findings provide possible explanations for beneficial or detrimental effects of eye drops.",

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author = "Valentini, {Caterina Giovanna} and Nuzzolo, {Eugenia Rosa} and N. Orlando and Elisabetta Metafuni and M. Bianchi and Patrizia Chiusolo and {Zini Tanzi}, Gina and Luciana Teofili",

year = "2016",

doi = "10.1111/vox.12325",

language = "English",

volume = "110",

pages = "189--192",

journal = "Vox Sanguinis",

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AU - Valentini, Caterina Giovanna

AU - Nuzzolo, Eugenia Rosa

AU - Orlando, N.

AU - Metafuni, Elisabetta

AU - Bianchi, M.

AU - Chiusolo, Patrizia

AU - Zini Tanzi, Gina

AU - Teofili, Luciana

PY - 2016

Y1 - 2016

N2 - Ocular chronic GVHD is efficaciously treated with autologous platelet-derived eye drops. We investigated the cytokine content of eye drops produced using a non-gelified lysate obtained from autologous platelet-rich plasma in six patients with ocular GVHD. In both the responding (n = 4) and the resistant (n = 2) patients, the eye drops were significantly enriched with various growth factors, in amounts proportional with the platelet counts. In contrast, chemokine ligand and interleukin levels were similar to those of plasma. The non-responding patients showed the highest levels of chemokine (C-X-C motif) ligand (CXCL)10. These findings provide possible explanations for beneficial or detrimental effects of eye drops.

AB - Ocular chronic GVHD is efficaciously treated with autologous platelet-derived eye drops. We investigated the cytokine content of eye drops produced using a non-gelified lysate obtained from autologous platelet-rich plasma in six patients with ocular GVHD. In both the responding (n = 4) and the resistant (n = 2) patients, the eye drops were significantly enriched with various growth factors, in amounts proportional with the platelet counts. In contrast, chemokine ligand and interleukin levels were similar to those of plasma. The non-responding patients showed the highest levels of chemokine (C-X-C motif) ligand (CXCL)10. These findings provide possible explanations for beneficial or detrimental effects of eye drops.

KW - Adult

KW - Autologous platelet lysates

KW - Blood Platelets

KW - Chemokines

KW - Cytokines

KW - Dry eye syndrome

KW - Female

KW - GVHD

KW - Graft vs Host Disease

KW - Growth factors

KW - Hematology

KW - Humans

KW - Male

KW - Middle Aged

KW - Ophthalmic Solutions

KW - Adult

KW - Autologous platelet lysates

KW - Blood Platelets

KW - Chemokines

KW - Cytokines

KW - Dry eye syndrome

KW - Female

KW - GVHD

KW - Graft vs Host Disease

KW - Growth factors

KW - Hematology

KW - Humans

KW - Male

KW - Middle Aged

KW - Ophthalmic Solutions

UR - http://hdl.handle.net/10807/94550

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U2 - 10.1111/vox.12325

DO - 10.1111/vox.12325

M3 - Article

SN - 0042-9007

VL - 110

SP - 189

EP - 192

JO - Vox Sanguinis

JF - Vox Sanguinis

ER -

Cytokine profile of autologous platelet-derived eye drops in patients with ocular chronic graft-versus-host disease

Abstract

Keywords

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