Current Prognostic and Predictive Biomarkers for Endometrial Cancer in Clinical Practice: Recommendations/Proposal from the Italian Study Group

Gian Franco Zannoni, Frediano Inzani, Emma Bragantini, Francesca Castiglione, Matteo Fassan, Giancarlo Troncone, Anna Pesci, Filippo Fraggetta

Research output: Contribution to journalArticle

Abstract

Endometrial carcinoma (EC) is the most common gynecological malignant disease in high-income countries, such as European countries and the USA. The 2020 edition of the World Health Organization (WHO) Classification of Tumors of the Female Genital Tract underlines the important clinical implications of the proposed new histomolecular classification system for ECs. In view of the substantial genetic and morphological heterogeneity in ECs, both classical pthological parameters and molecular classifiers have to be integrated in the pathology report. This review will focus on the most commonly adopted immunohistochemical and molecular biomarkers in daily clinical characterization of EC, referring to the most recent published recommendations, guidelines, and expert opinions.
Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalFrontiers in Oncology
Volume12
DOIs
Publication statusPublished - 2022

Keywords

  • endometrial cancer
  • histomolecular classification
  • prognostic stratification
  • prognostic markers
  • pathological guidelines

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