Current evidence on the safety profile of NSAIDs for the treatment of PDA.

Costantino Romagnoli, Iliana Bersani, Serafina Lacerenza, Maria Pia De Carolis, Serena Antonia Rubortone

Research output: Contribution to journalArticle

4 Citations (Scopus)


Patent ductus arteriosus (PDA) complicates the clinical course of preterm infants. Nonsteroidal anti-inflammatory drugs, especially Indomethacin and Ibuprofen, have been widely used for both prevention and treatment of PDA. Short-term efficacy of Indomethacin or Ibuprofen is equivalent, while Ibuprofen results show a higher safety profile. Ibuprofen is associated with fewer clinical gastrointestinal and renal side effects with respect to Indomethacin even if subclinical potential effects are reported. When administered as prophylaxis, Ibuprofen has no effects on prevention of intraventricular haemorrhage unlike Indomethacin. Considering the potential adverse effects of both these drugs, a careful monitoring during and after the treatment period is highly recommended.
Original languageEnglish
Pages (from-to)10-13
Number of pages4
Publication statusPublished - 2011


  • treatment of PDA


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