COVID-19 atypical Parsonage-Turner syndrome: a case report

Maria Beatrice Zazzara; Anna Modoni; Alessandra Bizzarro; Alessandra Lauria; Francesca Ciciarello; Cristina Pais; Vincenzo Galluzzo; Francesco Landi; Matteo Tostato; Francesco Landi; Elisa Gremese; Roberto Bernabei; Massimo Fantoni; Antonio Gasbarrini; Carlo Romano Settanni; Serena Porcari; Francesca Benvenuto; Giulia Bramato; Vincenzo Brandi; Angelo Carfì; Francesca Ciciarello; Maria Rita Lo Monaco; Anna Maria Martone; Emanuele Marzetti; Carmen Napolitano; Vincenzo Galluzzo; Francesco Pagano; Cristina Pais; Sara Rocchi; Elisabetta Rota; Andrea Salerno; Matteo Tosato; Marcello Tritto; Riccardo Calvani; Maria Beatrice Zazzara; Lucio Catalano; Anna Picca; Giulia Savera; Roberto Cauda; Rita Murri; Antonella Cingolani; Giulio Ventura; Eleonora Taddei; Davide Moschese; Arturo Ciccullo; Massimo Fantoni; Leonardo Stella; Giovanni Addolorato; Francesco Franceschi; Gertrude Mingrone; Maria Assunta Zocco; Maurizio Sanguinetti; Paola Cattani; Simona Marchetti; Brunella Posteraro; Michela Sali; Alessandra Bizzarro; Alessandra Lauria; Stanislao Rizzo; Maria Cristina Savastano; Gloria Gambini; Maria Grazia Cozzupoli; Carola Culiersi; Giulio Cesare Passali; Gaetano Paludetti; Jacopo Galli; Fabrizio Crudo; Giovanni Di Cintio; Ylenia Longobardi; Laura Tricarico; Mariaconsiglia Santantonio; Tiziana Di Cesare; Mariateresa Guarino; Marco Corbò; Stefano Settimi; Dario Mele; Francesca Brigato; Danilo Buonsenso; Piero Valentini; Dario Sinatti; Gabriella De Rose; Luca Richeldi; Francesco Lombardi; Angelo Calabrese; Francesco Varone; Paolo Maria Leone; Matteo Siciliano; Giuseppe Maria Corbo; Giuliano Montemurro; Mariarosaria Calvello; Enrica Intini; Jacopo Simonetti; Giuliana Pasciuto; Veronica Adiletta; Carmelo Sofia; Maria Angela Licata; Gabriele Sani; Delfina Janiri; Alessio Simonetti; Marco Modica; Silvia Montanari; Antonello Catinari; Beatrice Terenzi; Luigi Natale; Anna Rita Larici; Riccardo Marano; Tommaso Pirronti; Amato Infante; Annamaria Paglionico; Luca Petricca; Barbara Tolusso; Stefano Alivernini; Clara Di Mario; Angelo Santoliquido; Luca Santoro; Antonio Nesci; Angela Di Giorgio; null null

doi:10.1186/s12883-022-02622-4

COVID-19 atypical Parsonage-Turner syndrome: a case report

Maria Beatrice Zazzara^*, Anna Modoni, Alessandra Bizzarro, Alessandra Lauria, Francesca Ciciarello, Cristina Pais, Vincenzo Galluzzo, Francesco Landi, Matteo Tostato, Francesco Landi, Elisa Gremese, Roberto Bernabei, Massimo Fantoni, Antonio Gasbarrini, Carlo Romano Settanni, Serena Porcari, Francesca Benvenuto, Giulia Bramato, Vincenzo Brandi, Angelo CarfìFrancesca Ciciarello, Maria Rita Lo Monaco, Anna Maria Martone, Emanuele Marzetti, Carmen Napolitano, Vincenzo Galluzzo, Francesco Pagano, Cristina Pais, Sara Rocchi, Elisabetta Rota, Andrea Salerno, Matteo Tosato, Marcello Tritto, Riccardo Calvani, Maria Beatrice Zazzara^*, Lucio Catalano, Anna Picca, Giulia Savera, Roberto Cauda, Rita Murri, Antonella Cingolani, Giulio Ventura, Eleonora Taddei, Davide Moschese, Arturo Ciccullo, Massimo Fantoni, Leonardo Stella, Giovanni Addolorato, Francesco Franceschi, Gertrude Mingrone, Maria Assunta Zocco, Maurizio Sanguinetti, Paola Cattani, Simona Marchetti, Brunella Posteraro, Michela Sali, Alessandra Bizzarro, Alessandra Lauria, Stanislao Rizzo, Maria Cristina Savastano, Gloria Gambini, Maria Grazia Cozzupoli, Carola Culiersi, Giulio Cesare Passali, Gaetano Paludetti, Jacopo Galli, Fabrizio Crudo, Giovanni Di Cintio, Ylenia Longobardi, Laura Tricarico, Mariaconsiglia Santantonio, Tiziana Di Cesare, Mariateresa Guarino, Marco Corbò, Stefano Settimi, Dario Mele, Francesca Brigato, Danilo Buonsenso, Piero Valentini, Dario Sinatti, Gabriella De Rose, Luca Richeldi, Francesco Lombardi, Angelo Calabrese, Francesco Varone, Paolo Maria Leone, Matteo Siciliano, Giuseppe Maria Corbo, Giuliano Montemurro, Mariarosaria Calvello, Enrica Intini, Jacopo Simonetti, Giuliana Pasciuto, Veronica Adiletta, Carmelo Sofia, Maria Angela Licata, Gabriele Sani, Delfina Janiri, Alessio Simonetti, Marco Modica, Silvia Montanari, Antonello Catinari, Beatrice Terenzi, Luigi Natale, Anna Rita Larici, Riccardo Marano, Tommaso Pirronti, Amato Infante, Annamaria Paglionico, Luca Petricca, Barbara Tolusso, Stefano Alivernini, Clara Di Mario, Angelo Santoliquido, Luca Santoro, Antonio Nesci, Angela Di Giorgio, null null

^*Corresponding author

Research output: Contribution to journal › Article

Abstract

Background Neurological manifestations of Sars-CoV-2 infection have been described since March 2020 and include both central and peripheral nervous system manifestations. Neurological symptoms, such as headache or persistent loss of smell and taste, have also been documented in COVID-19 long-haulers. Moreover, long lasting fatigue, mild cognitive impairment and sleep disorders appear to be frequent long term neurological manifestations after hospitalization due to COVID-19. Less is known in relation to peripheral nerve injury related to Sars-CoV-2 infection. Case presentation We report the case of a 47-year-old female presenting with a unilateral chest pain radiating to the left arm lasting for more than two months after recovery from Sars-CoV-2 infection. After referral to our post-acute outpatient service for COVID-19 long haulers, she was diagnosed with a unilateral, atypical, pure sensory brachial plexus neuritis potentially related to COVID-19, which occurred during the acute phase of a mild Sars-CoV-2 infection and persisted for months after resolution of the infection. Conclusions We presented a case of atypical Parsonage-Turner syndrome potentially triggered by Sars-CoV-2 infection, with symptoms and repercussion lasting after viral clearance. A direct involvement of the virus remains uncertain, and the physiopathology is unclear. The treatment of COVID-19 and its long-term consequences represents a relatively new challenge for clinicians and health care providers. A multidisciplinary approach to following-up COVID-19 survivors is strongly advised.

Original language	English
Pages (from-to)	96-99
Number of pages	4
Journal	BMC Neurology
Volume	22
Issue number	1
DOIs	https://doi.org/10.1186/s12883-022-02622-4
Publication status	Published - 2022

All Science Journal Classification (ASJC) codes

Clinical Neurology

Keywords

Atypical brachial plexus neuritis
COVID-19 neurological manifestations
COVID-19 neuromuscular sequelae
Sars-CoV-2 infection

Access to Document

10.1186/s12883-022-02622-4

Cite this

Zazzara, M. B., Modoni, A., Bizzarro, A., Lauria, A., Ciciarello, F., Pais, C., Galluzzo, V., Landi, F., Tostato, M., Landi, F., Gremese, E., Bernabei, R., Fantoni, M., Gasbarrini, A., Settanni, C. R., Porcari, S., Benvenuto, F., Bramato, G., Brandi, V., ... null, N. (2022). COVID-19 atypical Parsonage-Turner syndrome: a case report. BMC Neurology, 22(1), 96-99. https://doi.org/10.1186/s12883-022-02622-4

@article{231c10653a074910b8b97aff973b65c3,

title = "COVID-19 atypical Parsonage-Turner syndrome: a case report",

abstract = "Background Neurological manifestations of Sars-CoV-2 infection have been described since March 2020 and include both central and peripheral nervous system manifestations. Neurological symptoms, such as headache or persistent loss of smell and taste, have also been documented in COVID-19 long-haulers. Moreover, long lasting fatigue, mild cognitive impairment and sleep disorders appear to be frequent long term neurological manifestations after hospitalization due to COVID-19. Less is known in relation to peripheral nerve injury related to Sars-CoV-2 infection. Case presentation We report the case of a 47-year-old female presenting with a unilateral chest pain radiating to the left arm lasting for more than two months after recovery from Sars-CoV-2 infection. After referral to our post-acute outpatient service for COVID-19 long haulers, she was diagnosed with a unilateral, atypical, pure sensory brachial plexus neuritis potentially related to COVID-19, which occurred during the acute phase of a mild Sars-CoV-2 infection and persisted for months after resolution of the infection. Conclusions We presented a case of atypical Parsonage-Turner syndrome potentially triggered by Sars-CoV-2 infection, with symptoms and repercussion lasting after viral clearance. A direct involvement of the virus remains uncertain, and the physiopathology is unclear. The treatment of COVID-19 and its long-term consequences represents a relatively new challenge for clinicians and health care providers. A multidisciplinary approach to following-up COVID-19 survivors is strongly advised.",

keywords = "Atypical brachial plexus neuritis, COVID-19 neurological manifestations, COVID-19 neuromuscular sequelae, Sars-CoV-2 infection, Atypical brachial plexus neuritis, COVID-19 neurological manifestations, COVID-19 neuromuscular sequelae, Sars-CoV-2 infection",

author = "Zazzara, {Maria Beatrice} and Anna Modoni and Alessandra Bizzarro and Alessandra Lauria and Francesca Ciciarello and Cristina Pais and Vincenzo Galluzzo and Francesco Landi and Matteo Tostato and Francesco Landi and Elisa Gremese and Roberto Bernabei and Massimo Fantoni and Antonio Gasbarrini and Settanni, {Carlo Romano} and Serena Porcari and Francesca Benvenuto and Giulia Bramato and Vincenzo Brandi and Angelo Carf{\`i} and Francesca Ciciarello and {Lo Monaco}, {Maria Rita} and Martone, {Anna Maria} and Emanuele Marzetti and Carmen Napolitano and Vincenzo Galluzzo and Francesco Pagano and Cristina Pais and Sara Rocchi and Elisabetta Rota and Andrea Salerno and Matteo Tosato and Marcello Tritto and Riccardo Calvani and Zazzara, {Maria Beatrice} and Lucio Catalano and Anna Picca and Giulia Savera and Roberto Cauda and Rita Murri and Antonella Cingolani and Giulio Ventura and Eleonora Taddei and Davide Moschese and Arturo Ciccullo and Massimo Fantoni and Leonardo Stella and Giovanni Addolorato and Francesco Franceschi and Gertrude Mingrone and Zocco, {Maria Assunta} and Maurizio Sanguinetti and Paola Cattani and Simona Marchetti and Brunella Posteraro and Michela Sali and Alessandra Bizzarro and Alessandra Lauria and Stanislao Rizzo and Savastano, {Maria Cristina} and Gloria Gambini and Cozzupoli, {Maria Grazia} and Carola Culiersi and Passali, {Giulio Cesare} and Gaetano Paludetti and Jacopo Galli and Fabrizio Crudo and {Di Cintio}, Giovanni and Ylenia Longobardi and Laura Tricarico and Mariaconsiglia Santantonio and {Di Cesare}, Tiziana and Mariateresa Guarino and Marco Corb{\`o} and Stefano Settimi and Dario Mele and Francesca Brigato and Danilo Buonsenso and Piero Valentini and Dario Sinatti and {De Rose}, Gabriella and Luca Richeldi and Francesco Lombardi and Angelo Calabrese and Francesco Varone and Leone, {Paolo Maria} and Matteo Siciliano and Corbo, {Giuseppe Maria} and Giuliano Montemurro and Mariarosaria Calvello and Enrica Intini and Jacopo Simonetti and Giuliana Pasciuto and Veronica Adiletta and Carmelo Sofia and Licata, {Maria Angela} and Gabriele Sani and Delfina Janiri and Alessio Simonetti and Marco Modica and Silvia Montanari and Antonello Catinari and Beatrice Terenzi and Luigi Natale and Larici, {Anna Rita} and Riccardo Marano and Tommaso Pirronti and Amato Infante and Annamaria Paglionico and Luca Petricca and Barbara Tolusso and Stefano Alivernini and {Di Mario}, Clara and Angelo Santoliquido and Luca Santoro and Antonio Nesci and {Di Giorgio}, Angela and null null",

year = "2022",

doi = "10.1186/s12883-022-02622-4",

language = "English",

volume = "22",

pages = "96--99",

journal = "BMC Neurology",

issn = "1471-2377",

publisher = "BioMed Central",

number = "1",

}

Zazzara, MB, Modoni, A, Bizzarro, A, Lauria, A, Ciciarello, F, Pais, C, Galluzzo, V, Landi, F, Tostato, M, Landi, F, Gremese, E, Bernabei, R, Fantoni, M, Gasbarrini, A, Settanni, CR, Porcari, S, Benvenuto, F, Bramato, G, Brandi, V, Carfì, A, Ciciarello, F, Lo Monaco, MR, Martone, AM , Marzetti, E, Napolitano, C, Galluzzo, V, Pagano, F, Pais, C, Rocchi, S, Rota, E, Salerno, A, Tosato, M, Tritto, M, Calvani, R, Zazzara, MB, Catalano, L, Picca, A, Savera, G, Cauda, R, Murri, R , Cingolani, A, Ventura, G, Taddei, E, Moschese, D, Ciccullo, A, Fantoni, M, Stella, L, Addolorato, G, Franceschi, F, Mingrone, G, Zocco, MA , Sanguinetti, M, Cattani, P, Marchetti, S, Posteraro, B , Sali, M, Bizzarro, A, Lauria, A, Rizzo, S , Savastano, MC , Gambini, G, Cozzupoli, MG, Culiersi, C, Passali, GC, Paludetti, G, Galli, J, Crudo, F, Di Cintio, G, Longobardi, Y, Tricarico, L, Santantonio, M, Di Cesare, T, Guarino, M, Corbò, M, Settimi, S, Mele, D, Brigato, F, Buonsenso, D, Valentini, P, Sinatti, D, De Rose, G, Richeldi, L, Lombardi, F, Calabrese, A, Varone, F, Leone, PM, Siciliano, M, Corbo, GM, Montemurro, G, Calvello, M, Intini, E, Simonetti, J, Pasciuto, G, Adiletta, V, Sofia, C, Licata, MA, Sani, G , Janiri, D, Simonetti, A, Modica, M, Montanari, S, Catinari, A, Terenzi, B, Natale, L , Larici, AR , Marano, R, Pirronti, T, Infante, A, Paglionico, A, Petricca, L, Tolusso, B, Alivernini, S, Di Mario, C, Santoliquido, A, Santoro, L, Nesci, A, Di Giorgio, A & null, N 2022, 'COVID-19 atypical Parsonage-Turner syndrome: a case report', BMC Neurology, vol. 22, no. 1, pp. 96-99. https://doi.org/10.1186/s12883-022-02622-4

TY - JOUR

T1 - COVID-19 atypical Parsonage-Turner syndrome: a case report

AU - Zazzara, Maria Beatrice

AU - Modoni, Anna

AU - Bizzarro, Alessandra

AU - Lauria, Alessandra

AU - Ciciarello, Francesca

AU - Pais, Cristina

AU - Galluzzo, Vincenzo

AU - Landi, Francesco

AU - Tostato, Matteo

AU - Landi, Francesco

AU - Gremese, Elisa

AU - Bernabei, Roberto

AU - Fantoni, Massimo

AU - Gasbarrini, Antonio

AU - Settanni, Carlo Romano

AU - Porcari, Serena

AU - Benvenuto, Francesca

AU - Bramato, Giulia

AU - Brandi, Vincenzo

AU - Carfì, Angelo

AU - Ciciarello, Francesca

AU - Lo Monaco, Maria Rita

AU - Martone, Anna Maria

AU - Marzetti, Emanuele

AU - Napolitano, Carmen

AU - Galluzzo, Vincenzo

AU - Pagano, Francesco

AU - Pais, Cristina

AU - Rocchi, Sara

AU - Rota, Elisabetta

AU - Salerno, Andrea

AU - Tosato, Matteo

AU - Tritto, Marcello

AU - Calvani, Riccardo

AU - Zazzara, Maria Beatrice

AU - Catalano, Lucio

AU - Picca, Anna

AU - Savera, Giulia

AU - Cauda, Roberto

AU - Murri, Rita

AU - Cingolani, Antonella

AU - Ventura, Giulio

AU - Taddei, Eleonora

AU - Moschese, Davide

AU - Ciccullo, Arturo

AU - Fantoni, Massimo

AU - Stella, Leonardo

AU - Addolorato, Giovanni

AU - Franceschi, Francesco

AU - Mingrone, Gertrude

AU - Zocco, Maria Assunta

AU - Sanguinetti, Maurizio

AU - Cattani, Paola

AU - Marchetti, Simona

AU - Posteraro, Brunella

AU - Sali, Michela

AU - Bizzarro, Alessandra

AU - Lauria, Alessandra

AU - Rizzo, Stanislao

AU - Savastano, Maria Cristina

AU - Gambini, Gloria

AU - Cozzupoli, Maria Grazia

AU - Culiersi, Carola

AU - Passali, Giulio Cesare

AU - Paludetti, Gaetano

AU - Galli, Jacopo

AU - Crudo, Fabrizio

AU - Di Cintio, Giovanni

AU - Longobardi, Ylenia

AU - Tricarico, Laura

AU - Santantonio, Mariaconsiglia

AU - Di Cesare, Tiziana

AU - Guarino, Mariateresa

AU - Corbò, Marco

AU - Settimi, Stefano

AU - Mele, Dario

AU - Brigato, Francesca

AU - Buonsenso, Danilo

AU - Valentini, Piero

AU - Sinatti, Dario

AU - De Rose, Gabriella

AU - Richeldi, Luca

AU - Lombardi, Francesco

AU - Calabrese, Angelo

AU - Varone, Francesco

AU - Leone, Paolo Maria

AU - Siciliano, Matteo

AU - Corbo, Giuseppe Maria

AU - Montemurro, Giuliano

AU - Calvello, Mariarosaria

AU - Intini, Enrica

AU - Simonetti, Jacopo

AU - Pasciuto, Giuliana

AU - Adiletta, Veronica

AU - Sofia, Carmelo

AU - Licata, Maria Angela

AU - Sani, Gabriele

AU - Janiri, Delfina

AU - Simonetti, Alessio

AU - Modica, Marco

AU - Montanari, Silvia

AU - Catinari, Antonello

AU - Terenzi, Beatrice

AU - Natale, Luigi

AU - Larici, Anna Rita

AU - Marano, Riccardo

AU - Pirronti, Tommaso

AU - Infante, Amato

AU - Paglionico, Annamaria

AU - Petricca, Luca

AU - Tolusso, Barbara

AU - Alivernini, Stefano

AU - Di Mario, Clara

AU - Santoliquido, Angelo

AU - Santoro, Luca

AU - Nesci, Antonio

AU - Di Giorgio, Angela

AU - null, null

PY - 2022

Y1 - 2022

N2 - Background Neurological manifestations of Sars-CoV-2 infection have been described since March 2020 and include both central and peripheral nervous system manifestations. Neurological symptoms, such as headache or persistent loss of smell and taste, have also been documented in COVID-19 long-haulers. Moreover, long lasting fatigue, mild cognitive impairment and sleep disorders appear to be frequent long term neurological manifestations after hospitalization due to COVID-19. Less is known in relation to peripheral nerve injury related to Sars-CoV-2 infection. Case presentation We report the case of a 47-year-old female presenting with a unilateral chest pain radiating to the left arm lasting for more than two months after recovery from Sars-CoV-2 infection. After referral to our post-acute outpatient service for COVID-19 long haulers, she was diagnosed with a unilateral, atypical, pure sensory brachial plexus neuritis potentially related to COVID-19, which occurred during the acute phase of a mild Sars-CoV-2 infection and persisted for months after resolution of the infection. Conclusions We presented a case of atypical Parsonage-Turner syndrome potentially triggered by Sars-CoV-2 infection, with symptoms and repercussion lasting after viral clearance. A direct involvement of the virus remains uncertain, and the physiopathology is unclear. The treatment of COVID-19 and its long-term consequences represents a relatively new challenge for clinicians and health care providers. A multidisciplinary approach to following-up COVID-19 survivors is strongly advised.

AB - Background Neurological manifestations of Sars-CoV-2 infection have been described since March 2020 and include both central and peripheral nervous system manifestations. Neurological symptoms, such as headache or persistent loss of smell and taste, have also been documented in COVID-19 long-haulers. Moreover, long lasting fatigue, mild cognitive impairment and sleep disorders appear to be frequent long term neurological manifestations after hospitalization due to COVID-19. Less is known in relation to peripheral nerve injury related to Sars-CoV-2 infection. Case presentation We report the case of a 47-year-old female presenting with a unilateral chest pain radiating to the left arm lasting for more than two months after recovery from Sars-CoV-2 infection. After referral to our post-acute outpatient service for COVID-19 long haulers, she was diagnosed with a unilateral, atypical, pure sensory brachial plexus neuritis potentially related to COVID-19, which occurred during the acute phase of a mild Sars-CoV-2 infection and persisted for months after resolution of the infection. Conclusions We presented a case of atypical Parsonage-Turner syndrome potentially triggered by Sars-CoV-2 infection, with symptoms and repercussion lasting after viral clearance. A direct involvement of the virus remains uncertain, and the physiopathology is unclear. The treatment of COVID-19 and its long-term consequences represents a relatively new challenge for clinicians and health care providers. A multidisciplinary approach to following-up COVID-19 survivors is strongly advised.

KW - Atypical brachial plexus neuritis

KW - COVID-19 neurological manifestations

KW - COVID-19 neuromuscular sequelae

KW - Sars-CoV-2 infection

KW - Atypical brachial plexus neuritis

KW - COVID-19 neurological manifestations

KW - COVID-19 neuromuscular sequelae

KW - Sars-CoV-2 infection

UR - https://publicatt.unicatt.it/handle/10807/273096

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85126660784&origin=inward

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85126660784&origin=inward

U2 - 10.1186/s12883-022-02622-4

DO - 10.1186/s12883-022-02622-4

M3 - Article

SN - 1471-2377

VL - 22

SP - 96

EP - 99

JO - BMC Neurology

JF - BMC Neurology

IS - 1

ER -

COVID-19 atypical Parsonage-Turner syndrome: a case report

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this