COVID-19 and hepatic involvement: The liver as a main actor of the pandemic novel

C. Napodano; K. Pocino; A. Stefanile; Mariapaola Marino; Luca Miele; F. Gulli; V. Basile; F. Pandolfi; Antonio Gasbarrini; G. L. Rapaccini; U. Basile

doi:10.1111/sji.12977

COVID-19 and hepatic involvement: The liver as a main actor of the pandemic novel

C. Napodano
, K. Pocino^*
, A. Stefanile
, Mariapaola Marino^*
, Luca Miele
, F. Gulli
, V. Basile
, F. Pandolfi
, Antonio Gasbarrini
, G. L. Rapaccini
, U. Basile

^*Corresponding author

Ospedale Madre Giuseppina Vannini
University of Rome Tor Vergata

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

In the natural history of SARS-CoV-2 infection, liver injury is frequent but quite mild and it is defined as any liver damage occurring during disease progression and treatment of infection in patients with or without pre-existing liver diseases. The underlying mechanisms for hepatic injury in patients with COVID-19 are still unclear but the liver damage in SARS-CoV-2 infection seems to be directly caused by virus-induced cytopathic effects. In this review, we will summarize all data of updated literature, regarding the relationship between SARS-CoV-2 infection, acute response and liver involvement. An overview will be given on liver injury, liver transplant and the possible consequences of COVID-19 in patients with pre-existing liver diseases.

Original language	English
Pages (from-to)	e12977-N/A
Journal	Scandinavian Journal of Immunology
Volume	2021
Issue number	Sep 15:e12977
DOIs	https://doi.org/10.1111/sji.12977
Publication status	Published - 2020

All Science Journal Classification (ASJC) codes

Immunology

Keywords

COVID-19
SARS-CoV-2
cytokine storm syndrome
liver diseases
liver transplantation

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10.1111/sji.12977

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title = "COVID-19 and hepatic involvement: The liver as a main actor of the pandemic novel",

abstract = "In the natural history of SARS-CoV-2 infection, liver injury is frequent but quite mild and it is defined as any liver damage occurring during disease progression and treatment of infection in patients with or without pre-existing liver diseases. The underlying mechanisms for hepatic injury in patients with COVID-19 are still unclear but the liver damage in SARS-CoV-2 infection seems to be directly caused by virus-induced cytopathic effects. In this review, we will summarize all data of updated literature, regarding the relationship between SARS-CoV-2 infection, acute response and liver involvement. An overview will be given on liver injury, liver transplant and the possible consequences of COVID-19 in patients with pre-existing liver diseases.",

keywords = "COVID-19, SARS-CoV-2, cytokine storm syndrome, liver diseases, liver transplantation, COVID-19, SARS-CoV-2, cytokine storm syndrome, liver diseases, liver transplantation",

author = "C. Napodano and K. Pocino and A. Stefanile and Mariapaola Marino and Luca Miele and F. Gulli and V. Basile and F. Pandolfi and Antonio Gasbarrini and Rapaccini, \{G. L.\} and U. Basile",

year = "2020",

doi = "10.1111/sji.12977",

language = "English",

volume = "2021",

pages = "e12977--N/A",

journal = "Scandinavian Journal of Immunology",

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number = "Sep 15:e12977",

}

TY - JOUR

T1 - COVID-19 and hepatic involvement: The liver as a main actor of the pandemic novel

AU - Napodano, C.

AU - Pocino, K.

AU - Stefanile, A.

AU - Marino, Mariapaola

AU - Miele, Luca

AU - Gulli, F.

AU - Basile, V.

AU - Pandolfi, F.

AU - Gasbarrini, Antonio

AU - Rapaccini, G. L.

AU - Basile, U.

PY - 2020

Y1 - 2020

N2 - In the natural history of SARS-CoV-2 infection, liver injury is frequent but quite mild and it is defined as any liver damage occurring during disease progression and treatment of infection in patients with or without pre-existing liver diseases. The underlying mechanisms for hepatic injury in patients with COVID-19 are still unclear but the liver damage in SARS-CoV-2 infection seems to be directly caused by virus-induced cytopathic effects. In this review, we will summarize all data of updated literature, regarding the relationship between SARS-CoV-2 infection, acute response and liver involvement. An overview will be given on liver injury, liver transplant and the possible consequences of COVID-19 in patients with pre-existing liver diseases.

AB - In the natural history of SARS-CoV-2 infection, liver injury is frequent but quite mild and it is defined as any liver damage occurring during disease progression and treatment of infection in patients with or without pre-existing liver diseases. The underlying mechanisms for hepatic injury in patients with COVID-19 are still unclear but the liver damage in SARS-CoV-2 infection seems to be directly caused by virus-induced cytopathic effects. In this review, we will summarize all data of updated literature, regarding the relationship between SARS-CoV-2 infection, acute response and liver involvement. An overview will be given on liver injury, liver transplant and the possible consequences of COVID-19 in patients with pre-existing liver diseases.

KW - COVID-19

KW - SARS-CoV-2

KW - cytokine storm syndrome

KW - liver diseases

KW - liver transplantation

KW - COVID-19

KW - SARS-CoV-2

KW - cytokine storm syndrome

KW - liver diseases

KW - liver transplantation

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U2 - 10.1111/sji.12977

DO - 10.1111/sji.12977

M3 - Article

SN - 0300-9475

VL - 2021

SP - e12977-N/A

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

IS - Sep 15:e12977

ER -

COVID-19 and hepatic involvement: The liver as a main actor of the pandemic novel

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

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