COVID-19 and hepatic involvement: The liver as a main actor of the pandemic novel

Cecilia Napodano, Krizia Pocino*, Annunziata Stefanile, Mariapaola Marino*, Luca Miele, Francesca Gulli, Valerio Basile, Franco Pandolfi, Antonio Gasbarrini, Gian Ludovico Rapaccini, Umberto Basile

*Corresponding author

Research output: Contribution to journalArticle

3 Citations (Scopus)


In the natural history of SARS-CoV-2 infection, liver injury is frequent but quite mild and it is defined as any liver damage occurring during disease progression and treatment of infection in patients with or without pre-existing liver diseases. The underlying mechanisms for hepatic injury in patients with COVID-19 are still unclear but the liver damage in SARS-CoV-2 infection seems to be directly caused by virus-induced cytopathic effects. In this review, we will summarize all data of updated literature, regarding the relationship between SARS-CoV-2 infection, acute response and liver involvement. An overview will be given on liver injury, liver transplant and the possible consequences of COVID-19 in patients with pre-existing liver diseases.
Original languageEnglish
Pages (from-to)e12977-N/A
JournalScandinavian Journal of Immunology
Publication statusPublished - 2020


  • COVID-19
  • SARS-CoV-2
  • cytokine storm syndrome
  • liver diseases
  • liver transplantation


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