COVID-19 and hepatic involvement: The liver as a main actor of the pandemic novel

Mariapaola Marino, Luca Miele, Antonio Gasbarrini, Gian Ludovico Rapaccini, Cecilia Napodano, Krizia Pocino, Annunziata Stefanile, Franco Pandolfi, Umberto Basile, Francesca Gulli, Valerio Basile

Research output: Contribution to journalArticle

3 Citations (Scopus)


In the natural history of SARS-CoV-2 infection, liver injury is frequent but quite mild and it is defined as any liver damage occurring during disease progression and treatment of infection in patients with or without pre-existing liver diseases. The underlying mechanisms for hepatic injury in patients with COVID-19 are still unclear but the liver damage in SARS-CoV-2 infection seems to be directly caused by virus-induced cytopathic effects. In this review, we will summarize all data of updated literature, regarding the relationship between SARS-CoV-2 infection, acute response and liver involvement. An overview will be given on liver injury, liver transplant and the possible consequences of COVID-19 in patients with pre-existing liver diseases.
Original languageEnglish
Pages (from-to)e12977-N/A
JournalScandinavian Journal of Immunology
Publication statusPublished - 2020


  • COVID-19
  • SARS-CoV-2
  • cytokine storm syndrome
  • liver diseases
  • liver transplantation


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