Correspondence between clinical improvement and proteomic changes of the salivary peptide complex in a child with primary Sjögren syndrome

Donato Rigante; Rosanna Inzitari; Maurizio Carone; Chiara Fanali; Achille Stabile; Tiziana Cabras; Ettore Capoluongo; Stefania Gaspari; Giuseppe Barone; Massimo Castagnola

doi:10.1007/s00296-008-0524-9

Correspondence between clinical improvement and proteomic changes of the salivary peptide complex in a child with primary Sjögren syndrome

Donato Rigante, Rosanna Inzitari, Maurizio Carone, Chiara Fanali, Achille Stabile, Tiziana Cabras, Ettore Capoluongo, Stefania Gaspari, Giuseppe Barone, Massimo Castagnola

Research output: Contribution to journal › Article

Abstract

The aberrant induction of salivary/lacrimal proteins is considered to be crucial in the pathogenesis of sicca-symptoms related to primary Sjögren syndrome (SS). We report the case of an 11-year-old boy who was admitted to hospital due to recurrent bilateral parotid gland enlargement and keratoconjunctivitis, which were diagnosed as primary SS upon a combination of laboratory and instrumental tests. The proteomic analysis of the salivary peptide complex in the patient's salivary fluid near diagnosis and after 6 months of pharmacological therapy revealed quantitative and mostly qualitative differences. This observation reveals that clinical and functional changes of the salivary glands driven by non-steroidal antinflammatory drugs might be reflected in different proteomic patterns of the salivary fluid. © 2008 Springer-Verlag.

Original language	English
Pages (from-to)	801-806
Number of pages	6
Journal	Rheumatology International
Volume	28
DOIs	https://doi.org/10.1007/s00296-008-0524-9
Publication status	Published - 2008

Keywords

Child
Salivary peptide complex
Primary Sjögren syndrome

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10.1007/s00296-008-0524-9

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title = "Correspondence between clinical improvement and proteomic changes of the salivary peptide complex in a child with primary Sj{\"o}gren syndrome",

abstract = "The aberrant induction of salivary/lacrimal proteins is considered to be crucial in the pathogenesis of sicca-symptoms related to primary Sj{\"o}gren syndrome (SS). We report the case of an 11-year-old boy who was admitted to hospital due to recurrent bilateral parotid gland enlargement and keratoconjunctivitis, which were diagnosed as primary SS upon a combination of laboratory and instrumental tests. The proteomic analysis of the salivary peptide complex in the patient's salivary fluid near diagnosis and after 6 months of pharmacological therapy revealed quantitative and mostly qualitative differences. This observation reveals that clinical and functional changes of the salivary glands driven by non-steroidal antinflammatory drugs might be reflected in different proteomic patterns of the salivary fluid. {\textcopyright} 2008 Springer-Verlag.",

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author = "Donato Rigante and Rosanna Inzitari and Maurizio Carone and Chiara Fanali and Achille Stabile and Tiziana Cabras and Ettore Capoluongo and Stefania Gaspari and Giuseppe Barone and Massimo Castagnola",

year = "2008",

doi = "10.1007/s00296-008-0524-9",

language = "English",

volume = "28",

pages = "801--806",

journal = "Rheumatology International",

issn = "0172-8172",

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TY - JOUR

T1 - Correspondence between clinical improvement and proteomic changes of the salivary peptide complex in a child with primary Sjögren syndrome

AU - Rigante, Donato

AU - Inzitari, Rosanna

AU - Carone, Maurizio

AU - Fanali, Chiara

AU - Stabile, Achille

AU - Cabras, Tiziana

AU - Capoluongo, Ettore

AU - Gaspari, Stefania

AU - Barone, Giuseppe

AU - Castagnola, Massimo

PY - 2008

Y1 - 2008

N2 - The aberrant induction of salivary/lacrimal proteins is considered to be crucial in the pathogenesis of sicca-symptoms related to primary Sjögren syndrome (SS). We report the case of an 11-year-old boy who was admitted to hospital due to recurrent bilateral parotid gland enlargement and keratoconjunctivitis, which were diagnosed as primary SS upon a combination of laboratory and instrumental tests. The proteomic analysis of the salivary peptide complex in the patient's salivary fluid near diagnosis and after 6 months of pharmacological therapy revealed quantitative and mostly qualitative differences. This observation reveals that clinical and functional changes of the salivary glands driven by non-steroidal antinflammatory drugs might be reflected in different proteomic patterns of the salivary fluid. © 2008 Springer-Verlag.

AB - The aberrant induction of salivary/lacrimal proteins is considered to be crucial in the pathogenesis of sicca-symptoms related to primary Sjögren syndrome (SS). We report the case of an 11-year-old boy who was admitted to hospital due to recurrent bilateral parotid gland enlargement and keratoconjunctivitis, which were diagnosed as primary SS upon a combination of laboratory and instrumental tests. The proteomic analysis of the salivary peptide complex in the patient's salivary fluid near diagnosis and after 6 months of pharmacological therapy revealed quantitative and mostly qualitative differences. This observation reveals that clinical and functional changes of the salivary glands driven by non-steroidal antinflammatory drugs might be reflected in different proteomic patterns of the salivary fluid. © 2008 Springer-Verlag.

KW - Child

KW - Salivary peptide complex

KW - Primary Sjögren syndrome

KW - Child

KW - Salivary peptide complex

KW - Primary Sjögren syndrome

UR - http://hdl.handle.net/10807/257418

U2 - 10.1007/s00296-008-0524-9

DO - 10.1007/s00296-008-0524-9

M3 - Article

SN - 0172-8172

VL - 28

SP - 801

EP - 806

JO - Rheumatology International

JF - Rheumatology International

ER -

Correspondence between clinical improvement and proteomic changes of the salivary peptide complex in a child with primary Sjögren syndrome

Abstract

Keywords

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