Correspondence between clinical improvement and proteomic changes of the salivary peptide complex ina child with primary Sjogren syndrome

Donato Rigante, Rosanna Inzitari, Chiara Fanali, Achille Stabile, Tiziana Cabras, Ettore Domenico Capoluongo, Giuseppe Barone, Massimo Castagnola, M. Carone, S. Gaspari

Research output: Contribution to journalArticlepeer-review

Abstract

The aberrant induction of salivary/lacrimal proteins is considered to be crucial in the pathogenesis of sicca-symptoms related to primary Sjögren syndrome (SS). We report the case of an 11-year-old boy who was admitted to hospital due to recurrent bilateral parotid gland enlargement and keratoconjunctivitis, which were diagnosed as primary SS upon a combination of laboratory and instrumental tests. The proteomic analysis of the salivary peptide complex in the patient's salivary fluid near diagnosis and after 6 months of pharmacological therapy revealed quantitative and mostly qualitative differences. This observation reveals that clinical and functional changes of the salivary glands driven by non-steroidal antinflammatory drugs might be reflected in different proteomic patterns of the salivary fluid.
Original languageEnglish
Pages (from-to)801-806
Number of pages6
JournalRheumatology International
Volume2008
Publication statusPublished - 2008

Keywords

  • Sjogren syndrome
  • child
  • salivary peptide

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