Coronary artery plaque rupture and erosion: Role of wall shear stress profiling and biological patterns in acute coronary syndromes

Giulio Russo, Daniela Pedicino, Claudio Chiastra, Ramona Vinci, Maurizio Lodi Rizzini, Lorenzo Genuardi, Mohammad Sarraf, Alessia D'Aiello, Marco Bologna, Cristina Aurigemma, Alice Bonanni, Antonio Bellantoni, Fabrizio D'Ascenzo, Pellegrino Ciampi, Aniello Zambrano, Luca Mainardi, Myriana Ponzo, Anna Severino, Carlo Trani, Massimo MassettiDiego Gallo, Francesco Migliavacca, Francesco Maisano, Amir Lerman, Umberto Morbiducci, Francesco Burzotta, Filippo Crea, Giovanna Liuzzo

Research output: Contribution to journalArticle

Abstract

Wall shear stress (WSS) is involved in coronary artery plaque pathological mechanisms and modulation of gene expression. This study aims to provide a comprehensive haemodynamic and biological description of unstable (intact-fibrous-cap, IFC, and ruptured-fibrous-cap, RFC) and stable (chronic coronary syndrome, CCS) plaques and investigate any correlation between WSS and molecular pathways.
Original languageEnglish
Pages (from-to)N/A-N/A
JournalInternational Journal of Cardiology
DOIs
Publication statusPublished - 2022

Keywords

  • Acute coronary syndrome
  • Computational fluid dynamics
  • Personalized medicine
  • Plaque erosion
  • Plaque rupture
  • Shear stress
  • Vulnerable plaque

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