Constitutive and cytokine-induced expression of MHC and intercellular adhesion molecule-1 (ICAM-1) on human myoblasts

Mariapaola Marino; Flavia Scuderi; Paola Mazzarelli; Francesca Mannella; Carlo Provenzano; Emanuela Bartoccioni

doi:10.1016/S0165-5728(01)00287-9

Constitutive and cytokine-induced expression of MHC and intercellular adhesion molecule-1 (ICAM-1) on human myoblasts

Mariapaola Marino, Flavia Scuderi, Paola Mazzarelli, Francesca Mannella, Carlo Provenzano, Emanuela Bartoccioni^*

^*Corresponding author

Research output: Contribution to journal › Article

34 Citations (Scopus)

Abstract

We studied the expression of MHC-I and MHC-II molecules and ICAM-1 in cultured human myoblasts in response to IL-1β, IL-4, IL-6, IFN-γ and LPS. IFN-γ, LPS and IL-4 greatly increase MHC-I molecule expression. MHC-II molecule expression is induced only by IFN-γ. Membrane ICAM-1 and mRNA expression are absent under basal conditions, but can be induced by IFN-γ, IL-1β, IL-4, LPS and IL-6 with different efficiencies and time-courses. Soluble ICAM-1 secretion can be induced to a different extent by all cytokines. Our study shows that the expression of adhesion-related molecules in muscle is finely regulated by these cytokines. © 2001 Elsevier Science B.V.

Original language	English
Pages (from-to)	94-101
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	116
DOIs	https://doi.org/10.1016/S0165-5728(01)00287-9
Publication status	Published - 2001

Keywords

Cells, Cultured
Cytokine
Cytokines
DNA vaccination
Flow Cytometry
Gene therapy
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Humans
Inflammatory myopathies
Intercellular Adhesion Molecule-1
MHC
Muscle, Skeletal
Myoblast
RNA, Messenger

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0165-5728(01)00287-9

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title = "Constitutive and cytokine-induced expression of MHC and intercellular adhesion molecule-1 (ICAM-1) on human myoblasts",

abstract = "We studied the expression of MHC-I and MHC-II molecules and ICAM-1 in cultured human myoblasts in response to IL-1β, IL-4, IL-6, IFN-γ and LPS. IFN-γ, LPS and IL-4 greatly increase MHC-I molecule expression. MHC-II molecule expression is induced only by IFN-γ. Membrane ICAM-1 and mRNA expression are absent under basal conditions, but can be induced by IFN-γ, IL-1β, IL-4, LPS and IL-6 with different efficiencies and time-courses. Soluble ICAM-1 secretion can be induced to a different extent by all cytokines. Our study shows that the expression of adhesion-related molecules in muscle is finely regulated by these cytokines. {\textcopyright} 2001 Elsevier Science B.V.",

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author = "Mariapaola Marino and Flavia Scuderi and Paola Mazzarelli and Francesca Mannella and Carlo Provenzano and Emanuela Bartoccioni",

year = "2001",

doi = "10.1016/S0165-5728(01)00287-9",

language = "English",

volume = "116",

pages = "94--101",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Constitutive and cytokine-induced expression of MHC and intercellular adhesion molecule-1 (ICAM-1) on human myoblasts

AU - Marino, Mariapaola

AU - Scuderi, Flavia

AU - Mazzarelli, Paola

AU - Mannella, Francesca

AU - Provenzano, Carlo

AU - Bartoccioni, Emanuela

PY - 2001

Y1 - 2001

N2 - We studied the expression of MHC-I and MHC-II molecules and ICAM-1 in cultured human myoblasts in response to IL-1β, IL-4, IL-6, IFN-γ and LPS. IFN-γ, LPS and IL-4 greatly increase MHC-I molecule expression. MHC-II molecule expression is induced only by IFN-γ. Membrane ICAM-1 and mRNA expression are absent under basal conditions, but can be induced by IFN-γ, IL-1β, IL-4, LPS and IL-6 with different efficiencies and time-courses. Soluble ICAM-1 secretion can be induced to a different extent by all cytokines. Our study shows that the expression of adhesion-related molecules in muscle is finely regulated by these cytokines. © 2001 Elsevier Science B.V.

AB - We studied the expression of MHC-I and MHC-II molecules and ICAM-1 in cultured human myoblasts in response to IL-1β, IL-4, IL-6, IFN-γ and LPS. IFN-γ, LPS and IL-4 greatly increase MHC-I molecule expression. MHC-II molecule expression is induced only by IFN-γ. Membrane ICAM-1 and mRNA expression are absent under basal conditions, but can be induced by IFN-γ, IL-1β, IL-4, LPS and IL-6 with different efficiencies and time-courses. Soluble ICAM-1 secretion can be induced to a different extent by all cytokines. Our study shows that the expression of adhesion-related molecules in muscle is finely regulated by these cytokines. © 2001 Elsevier Science B.V.

KW - Cells, Cultured

KW - Cytokine

KW - Cytokines

KW - DNA vaccination

KW - Flow Cytometry

KW - Gene therapy

KW - Histocompatibility Antigens Class I

KW - Histocompatibility Antigens Class II

KW - Humans

KW - Inflammatory myopathies

KW - Intercellular Adhesion Molecule-1

KW - MHC

KW - Muscle, Skeletal

KW - Myoblast

KW - RNA, Messenger

KW - Cells, Cultured

KW - Cytokine

KW - Cytokines

KW - DNA vaccination

KW - Flow Cytometry

KW - Gene therapy

KW - Histocompatibility Antigens Class I

KW - Histocompatibility Antigens Class II

KW - Humans

KW - Inflammatory myopathies

KW - Intercellular Adhesion Molecule-1

KW - MHC

KW - Muscle, Skeletal

KW - Myoblast

KW - RNA, Messenger

UR - http://hdl.handle.net/10807/163610

U2 - 10.1016/S0165-5728(01)00287-9

DO - 10.1016/S0165-5728(01)00287-9

M3 - Article

SN - 0165-5728

VL - 116

SP - 94

EP - 101

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Constitutive and cytokine-induced expression of MHC and intercellular adhesion molecule-1 (ICAM-1) on human myoblasts

Abstract

Keywords

UN SDGs

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