Conjunctival melanoma: Genetic and epigenetic insights of a distinct type of melanoma

Giovanni Schinzari, Emilio Bria, Ketty Peris, Maria Antonietta Blasi, Giampaolo Tortora, Ernesto Rossi, Brigida Anna Maiorano, Monica Maria Pagliara, Alessandro Di Stefani

Research output: Contribution to journalArticle

8 Citations (Scopus)


Conjunctival melanoma (CjM) is a rare, primary cancer of the ocular region. Genetic and epigenetic characteristics of conjunctival melanoma have not been completely elucidated yet. Conjunctival melanoma presents similarities with cutaneous melanoma, with substantial differences in the biological behavior. We reviewed the genetic and epigenetic insights of CjM involved in invasion and metastatic spread. CjM is commonly characterized by mutations of v-raf murine sarcoma viral oncogene homolog B1 (BRAF), neurofibromin 1 (NF1) and telomerase reverse transcriptase (TERT), high expression of mammalian target of rapamycin (mTOR) and heat shock protein 90 (HSP90), frequent phosphatase and tensin homolog (PTEN) loss and upregulation of specific miRNAs. These features should identify CjM as a distinct subset of melanoma with its own profile, which is more similar to cutaneous melanoma than mucosal melanoma and remarkably different from uveal melanoma.
Original languageEnglish
Pages (from-to)5447-5464
Number of pages18
JournalInternational Journal of Molecular Sciences
Publication statusPublished - 2019


  • BRAF
  • Conjunctival
  • EZH2
  • Genetic
  • Melanoma
  • MiRNA
  • NF1
  • NRAS


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