Confirming the limited role of CA-125 for adnexal mass diagnosis

B Van Calster; C Van Holsbeke; R Fruscio; Aa Lissoni; S Guerriero; L Valentin; A Czekierdowski; N Colombo; E De Jonge; D Fischerova; Antonia Carla Testa; S Van Huffel; T Bourne; D. Timmerman

doi:10.1002/uog.5555

Confirming the limited role of CA-125 for adnexal mass diagnosis

B Van Calster, C Van Holsbeke, R Fruscio, Aa Lissoni, S Guerriero, L Valentin, A Czekierdowski, N Colombo, E De Jonge, D Fischerova, Antonia Carla Testa, S Van Huffel, T Bourne, D. Timmerman

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

To prospectively evaluate the results of the CA-125 analyses performed on the IOTA (International Ovarian Tumor Analysis group) phase 1 data. Jump to… Methods Top of page Objectives Methods Results Conclusions Using the IOTA phase 1 data, logistic regression models with and without CA-125 as a predictor were developed to predict malignancy of ovarian tumors in pre- and postmenopausal women. These models were applied to the prospectively collected data from phase 2 (n = 1940). Their performance was evaluated using receiver operating characteristic (ROC) curves, area under the curve (AUC), and the sensitivity at 75% specificity (Sens75). Next, the performance of the expert operator's subjective impression (pattern recognition) was compared to CA-125 alone, and the median CA-125 level was computed for each histological endpoint. To this end, the data from IOTA phases 1, 1b, and 2 were used (n = 3513). Jump to… Results Top of page Objectives Methods Results Conclusions In premenopausal women, the logistic regression models with and without CA-125 had AUCs of 0.940 and 0.939, respectively. Sens75 levels were 94.2 and 95.9%. For postmenopausal women, the models with and without CA-125 had AUC values of 0.937 and 0.920, respectively, with Sens75 levels of 91.3 and 92.0%. The ROC curves for models with and without CA-125 were nearly identical in their top left part where sensitivity and specificity are high. Pattern recognition (sensitivity 92%, specificity 90%) clearly performed better than CA-125 alone. CA-125 levels were high in endometriomas (median = 20 U/ml) and abscesses (40 U/ml). Borderline stage I tumors had a median CA-125 level of 29 U/ml, rare primary invasive tumors of 52 U/ml. The highest CA-125 levels were obtained for primary invasive tumors of stage II–IV. Jump to… Conclusions Top of page Objectives Methods Results Conclusions The results confirmed our previous conclusions regarding the role of CA-125 in ovarian tumor diagnosis. This marker need not be used

Original language	English
Title of host publication	Special Issue: 18th World Congresson Ultrasound in Obstetrics and Gynecology
Pages	290-291
Number of pages	2
DOIs	https://doi.org/10.1002/uog.5555
Publication status	Published - 2008
Event	Annual International Congress - Chicago Duration: 24 Aug 2008 → 28 Aug 2008

Conference

Conference	Annual International Congress
City	Chicago
Period	24/8/08 → 28/8/08

Keywords

CA-125 adnexal mass diagnosis
ultrasound

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10.1002/uog.5555

Cite this

Van Calster, B., Van Holsbeke, C., Fruscio, R., Lissoni, A., Guerriero, S., Valentin, L., Czekierdowski, A., Colombo, N., De Jonge, E., Fischerova, D., Testa, A. C., Van Huffel, S., Bourne, T., & Timmerman, D. (2008). Confirming the limited role of CA-125 for adnexal mass diagnosis. In Special Issue: 18th World Congresson Ultrasound in Obstetrics and Gynecology (pp. 290-291) https://doi.org/10.1002/uog.5555

@inproceedings{9da39977cd824a87b91f28cf477b67ae,

title = "Confirming the limited role of CA-125 for adnexal mass diagnosis",

abstract = "To prospectively evaluate the results of the CA-125 analyses performed on the IOTA (International Ovarian Tumor Analysis group) phase 1 data. Jump to… Methods Top of page Objectives Methods Results Conclusions Using the IOTA phase 1 data, logistic regression models with and without CA-125 as a predictor were developed to predict malignancy of ovarian tumors in pre- and postmenopausal women. These models were applied to the prospectively collected data from phase 2 (n = 1940). Their performance was evaluated using receiver operating characteristic (ROC) curves, area under the curve (AUC), and the sensitivity at 75% specificity (Sens75). Next, the performance of the expert operator's subjective impression (pattern recognition) was compared to CA-125 alone, and the median CA-125 level was computed for each histological endpoint. To this end, the data from IOTA phases 1, 1b, and 2 were used (n = 3513). Jump to… Results Top of page Objectives Methods Results Conclusions In premenopausal women, the logistic regression models with and without CA-125 had AUCs of 0.940 and 0.939, respectively. Sens75 levels were 94.2 and 95.9%. For postmenopausal women, the models with and without CA-125 had AUC values of 0.937 and 0.920, respectively, with Sens75 levels of 91.3 and 92.0%. The ROC curves for models with and without CA-125 were nearly identical in their top left part where sensitivity and specificity are high. Pattern recognition (sensitivity 92%, specificity 90%) clearly performed better than CA-125 alone. CA-125 levels were high in endometriomas (median = 20 U/ml) and abscesses (40 U/ml). Borderline stage I tumors had a median CA-125 level of 29 U/ml, rare primary invasive tumors of 52 U/ml. The highest CA-125 levels were obtained for primary invasive tumors of stage II–IV. Jump to… Conclusions Top of page Objectives Methods Results Conclusions The results confirmed our previous conclusions regarding the role of CA-125 in ovarian tumor diagnosis. This marker need not be used",

keywords = "CA-125 adnexal mass diagnosis, ultrasound, CA-125 adnexal mass diagnosis, ultrasound",

author = "{Van Calster}, B and {Van Holsbeke}, C and R Fruscio and Aa Lissoni and S Guerriero and L Valentin and A Czekierdowski and N Colombo and {De Jonge}, E and D Fischerova and Testa, {Antonia Carla} and {Van Huffel}, S and T Bourne and D. Timmerman",

year = "2008",

doi = "10.1002/uog.5555",

language = "English",

isbn = "0960-7692",

pages = "290--291",

booktitle = "Special Issue: 18th World Congresson Ultrasound in Obstetrics and Gynecology",

note = "Annual International Congress ; Conference date: 24-08-2008 Through 28-08-2008",

}

Van Calster, B, Van Holsbeke, C, Fruscio, R, Lissoni, A, Guerriero, S, Valentin, L, Czekierdowski, A, Colombo, N, De Jonge, E, Fischerova, D, Testa, AC, Van Huffel, S, Bourne, T & Timmerman, D 2008, Confirming the limited role of CA-125 for adnexal mass diagnosis. in Special Issue: 18th World Congresson Ultrasound in Obstetrics and Gynecology. pp. 290-291, Annual International Congress, Chicago, 24/8/08. https://doi.org/10.1002/uog.5555

TY - GEN

T1 - Confirming the limited role of CA-125 for adnexal mass diagnosis

AU - Van Calster, B

AU - Van Holsbeke, C

AU - Fruscio, R

AU - Lissoni, Aa

AU - Guerriero, S

AU - Valentin, L

AU - Czekierdowski, A

AU - Colombo, N

AU - De Jonge, E

AU - Fischerova, D

AU - Testa, Antonia Carla

AU - Van Huffel, S

AU - Bourne, T

AU - Timmerman, D.

PY - 2008

Y1 - 2008

N2 - To prospectively evaluate the results of the CA-125 analyses performed on the IOTA (International Ovarian Tumor Analysis group) phase 1 data. Jump to… Methods Top of page Objectives Methods Results Conclusions Using the IOTA phase 1 data, logistic regression models with and without CA-125 as a predictor were developed to predict malignancy of ovarian tumors in pre- and postmenopausal women. These models were applied to the prospectively collected data from phase 2 (n = 1940). Their performance was evaluated using receiver operating characteristic (ROC) curves, area under the curve (AUC), and the sensitivity at 75% specificity (Sens75). Next, the performance of the expert operator's subjective impression (pattern recognition) was compared to CA-125 alone, and the median CA-125 level was computed for each histological endpoint. To this end, the data from IOTA phases 1, 1b, and 2 were used (n = 3513). Jump to… Results Top of page Objectives Methods Results Conclusions In premenopausal women, the logistic regression models with and without CA-125 had AUCs of 0.940 and 0.939, respectively. Sens75 levels were 94.2 and 95.9%. For postmenopausal women, the models with and without CA-125 had AUC values of 0.937 and 0.920, respectively, with Sens75 levels of 91.3 and 92.0%. The ROC curves for models with and without CA-125 were nearly identical in their top left part where sensitivity and specificity are high. Pattern recognition (sensitivity 92%, specificity 90%) clearly performed better than CA-125 alone. CA-125 levels were high in endometriomas (median = 20 U/ml) and abscesses (40 U/ml). Borderline stage I tumors had a median CA-125 level of 29 U/ml, rare primary invasive tumors of 52 U/ml. The highest CA-125 levels were obtained for primary invasive tumors of stage II–IV. Jump to… Conclusions Top of page Objectives Methods Results Conclusions The results confirmed our previous conclusions regarding the role of CA-125 in ovarian tumor diagnosis. This marker need not be used

AB - To prospectively evaluate the results of the CA-125 analyses performed on the IOTA (International Ovarian Tumor Analysis group) phase 1 data. Jump to… Methods Top of page Objectives Methods Results Conclusions Using the IOTA phase 1 data, logistic regression models with and without CA-125 as a predictor were developed to predict malignancy of ovarian tumors in pre- and postmenopausal women. These models were applied to the prospectively collected data from phase 2 (n = 1940). Their performance was evaluated using receiver operating characteristic (ROC) curves, area under the curve (AUC), and the sensitivity at 75% specificity (Sens75). Next, the performance of the expert operator's subjective impression (pattern recognition) was compared to CA-125 alone, and the median CA-125 level was computed for each histological endpoint. To this end, the data from IOTA phases 1, 1b, and 2 were used (n = 3513). Jump to… Results Top of page Objectives Methods Results Conclusions In premenopausal women, the logistic regression models with and without CA-125 had AUCs of 0.940 and 0.939, respectively. Sens75 levels were 94.2 and 95.9%. For postmenopausal women, the models with and without CA-125 had AUC values of 0.937 and 0.920, respectively, with Sens75 levels of 91.3 and 92.0%. The ROC curves for models with and without CA-125 were nearly identical in their top left part where sensitivity and specificity are high. Pattern recognition (sensitivity 92%, specificity 90%) clearly performed better than CA-125 alone. CA-125 levels were high in endometriomas (median = 20 U/ml) and abscesses (40 U/ml). Borderline stage I tumors had a median CA-125 level of 29 U/ml, rare primary invasive tumors of 52 U/ml. The highest CA-125 levels were obtained for primary invasive tumors of stage II–IV. Jump to… Conclusions Top of page Objectives Methods Results Conclusions The results confirmed our previous conclusions regarding the role of CA-125 in ovarian tumor diagnosis. This marker need not be used

KW - CA-125 adnexal mass diagnosis

KW - ultrasound

KW - CA-125 adnexal mass diagnosis

KW - ultrasound

UR - http://hdl.handle.net/10807/28180

U2 - 10.1002/uog.5555

DO - 10.1002/uog.5555

M3 - Conference contribution

SN - 0960-7692

SP - 290

EP - 291

BT - Special Issue: 18th World Congresson Ultrasound in Obstetrics and Gynecology

T2 - Annual International Congress

Y2 - 24 August 2008 through 28 August 2008

ER -

Confirming the limited role of CA-125 for adnexal mass diagnosis

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Keywords

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