Complications related to hyperthermia during hypertermic intraoperative intraperitoneal chemiotherapy (HIPEC) treatment. Do they exist?

Sergio Alfieri, Dario Di Miceli, Roberta Menghi, Giuseppe Quero, Caterina Cina, Marco Pericoli Ridolfini, Giovanni Doglietto

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Hyperthermia, either alone or in combination with anticancer drugs, is becoming more and more a clinical reality for the treatment of far advanced gastrointestinal cancers, acting as a cytotoxic agent at a temperature between 40-42.5 degrees C. Although hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) is demonstrated to have some benefit in selected patients with peritoneal seeding, there are not enough data on the risk of damage of normal tissue that increases as the temperature rises, with possible serious and, sometimes, lethal complications.
Original languageEnglish
Pages (from-to)737-742
Number of pages6
JournalEuropean Review for Medical and Pharmacological Sciences
Volume16
Publication statusPublished - 2012

Keywords

  • Antineoplastic Agents
  • Combined Modality Therapy
  • Humans
  • Hyperthermia, Induced
  • Peritoneal Neoplasms

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